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No effects of Hypericum-containing complex on dolutegravir plasma trough concentrations: a case report

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References

  1. Russo E, Scicchitano F, Whalley BJ, Mazzitello C, Ciriaco M, Esposito S, Patanè M, Upton R, Pugliese M, Chimirri S, Mammì M, Palleria C, de Sarro G (2014) Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions. Phytother Res 28:643–655

    Article  CAS  PubMed  Google Scholar 

  2. Di Carlo G, Borrelli F, Ernst E, Izzo AA (2001) St John’s wort: Prozac from the plant kingdom. Trends Pharmacol Sci 22:292–297

    Article  PubMed  Google Scholar 

  3. Brooks KM, George JM, Kumar P (2017) Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter products. Expert Rev Clin Pharmacol 10:59–79

    Article  CAS  PubMed  Google Scholar 

  4. Borrelli F, Izzo AA (2009) Herb-drug interactions with St John’s wort (Hypericum perforatum): an update on clinical observations. AAPS J 11:710–727

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cattaneo D, Capetti A, Rizzardini G (2019) Drug-drug interactions of a two-drug regimen of dolutegravir and lamivudine for HIV treatment. Expert Opin Drug Metab Toxicol 15:245–252

    Article  CAS  PubMed  Google Scholar 

  6. Tivicay Product Monograph - ViiV Healthcare Canada. Available at https://www.viivhealthcare.ca/media/151925/tivicay.pdf (last access June 6, 2019)

  7. Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, Willson TM, Collins JL, Kliewer SA (2000) St. John’s wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci U S A 97:7500–7502

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mannel M (2004) Drug interactions with St John’s wort: mechanisms and clinical implications. Drug Saf 27:773–797

    Article  CAS  PubMed  Google Scholar 

  9. Chrubasik-Hausmann S, Vlachojannis J, McLachlan AJ (2019) Understanding drug interactions with St John’s wort (Hypericum perforatum L.): impact of hyperforin content. J Pharm Pharmacol 71:129–138

    Article  CAS  PubMed  Google Scholar 

  10. Borghetti A, Calcagno A, Lombardi F, Cusato J, Belmonti S, D'Avolio A et al (2019) SLC22A2 variants and dolutegravir levels correlate with psychiatric symptoms in persons with HIV. J Antimicrob Chemother 74:1035–1043

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Gestione Ambulatoriale Politerapie (GAP) outpatient clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy

    Dario Cattaneo & Cristina Gervasoni

  2. Unit of Clinical Pharmacology, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy

    Dario Cattaneo & Marta Fusi

  3. Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy

    Cristina Gervasoni

Authors
  1. Dario Cattaneo
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  2. Marta Fusi
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  3. Cristina Gervasoni
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Contributions

DC and CG supervised all the stages of the study and wrote the first draft of the manuscript. MF performed pharmacokinetic analyses and revised the draft manuscript.

Corresponding author

Correspondence to Dario Cattaneo.

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The authors declare that they have no conflict of interest.

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Cattaneo, D., Fusi, M. & Gervasoni, C. No effects of Hypericum-containing complex on dolutegravir plasma trough concentrations: a case report. Eur J Clin Pharmacol 75, 1467–1468 (2019). https://doi.org/10.1007/s00228-019-02714-0

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  • DOI: https://doi.org/10.1007/s00228-019-02714-0

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