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Glucose metabolism in different regions of the rat brain under hypokinetic stress influenceGlucose metabolism in rats kept under long term hypokinetic stress was studied in 7 brain regions. Determination was made of the regional levels of glucose, lactate, glutamate, glutamine, aspartate, gamma-aminobutyrate and the incorporation of C-14 from plasma glucose into these metabolites, in glycogen and protein. From the content and activity data the regional glucose flux was approximated quantitatively. Under normal conditions the activity gradient cortex and frontal pole cerebellum, thalamus and mesencephalon, hypothalamus and pons and medulla is identical with that of the regional blood supply (measured with I131 serum albumin as the blood marker). Within the first days of immobilization a functional hypoxia occurred in all brain regions and the utilization of cycle amino acids for protein synthesis was strongly diminished. After the first week of stress the capillary volumes of all regions increased, aerobic glucose metabolism was enhanced (factors 1.3 - 2.0) and the incorporation of glucose C-14 via cycle amino acids into protein was considerably potentiated. The metabolic parameters normalized between the 7th and 11th week of stress. Blood supply and metabolic rate increased most in the hypothalamus.
Document ID
19800008458
Acquisition Source
Legacy CDMS
Document Type
Technical Memorandum (TM)
Authors
Konitzer, K. (Acad. of Sci. of the Ger. Democratic Republic)
Voigt, S. (Acad. of Sci. of the Ger. Democratic Republic)
Date Acquired
September 4, 2013
Publication Date
January 1, 1980
Subject Category
Life Sciences (General)
Report/Patent Number
NASA-TM-75949
Accession Number
80N16718
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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