Overview
- Provides a comprehensive summary of M2 macrophage functions
- Fills an important gap in the literature on leukocyte biology
- Can be used as a textbook or reference guide
Part of the book series: Progress in Inflammation Research (PIR, volume 86)
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About this book
Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
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Table of contents (12 chapters)
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Part I
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Part II
Authors and Affiliations
About the author
Bibliographic Information
Book Title: The M2 Macrophage
Authors: Tamás Röszer
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-030-50480-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-50479-3Published: 04 August 2020
Softcover ISBN: 978-3-030-50482-3Published: 05 August 2021
eBook ISBN: 978-3-030-50480-9Published: 03 August 2020
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XIII, 224
Number of Illustrations: 1 b/w illustrations
Topics: Immunology, Cell Biology, Lipidology, Infectious Diseases, Human Physiology