Abstract
THE mammalian fœtus must differ antigenically from the mother, except in highly inbred strains. Consequently the placenta is, in effect, a homograft. The problem of how the placenta is maintained in the uterus throughout pregnancy without eliciting an apparent homograft rejection reaction has not been solved satisfactorily, as yet. It would seem inevitable that immunological factors must play some part in placentation. The use of inbred lines of mice provides a means of investigating whether anti-genie differences between mother and offspring play a part in determining placental size.
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BILLINGTON, W. Influence of Immunological Dissimilarity of Mother and Fœtus on Size of Placenta in Mice. Nature 202, 317–318 (1964). https://doi.org/10.1038/202317a0
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DOI: https://doi.org/10.1038/202317a0
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