Abstract
SOME studies of the interaction of narcotic analgesics and brain monoamine systems have implicated brain monoamines in acute and long term effects of the principal narcotics1, but interspecies variation makes it difficult to apply these results to man. Techniques are now available which use monoamine metabolites in cerebrospinal fluid (CSF) as indicators of central monoamine metabolism2–4. Using measures which reflect central 5-hydroxytryptamine (serotonin) and dopamine synthesis, we studied patients on methadone maintenance therapy for heroin addiction.
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BOWERS, M., KLEBER, H. & DAVIS, L. Acid Monoamine Metabolites in Cerebrospinal Fluid during Methadone Maintenance. Nature 232, 581–582 (1971). https://doi.org/10.1038/232581a0
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DOI: https://doi.org/10.1038/232581a0
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