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Synthetic RNA-dependent DNA Polymerase Activity in Normal Rat Liver and Hepatomas

Nature volume 237, pages 499–503 (1972)Cite this article

Abstract

Normal adult rat liver contains a high level of a synthetic RNA-dependent DNA polymerase activity, which is distinct from cellular DNA-dependent polymerases. It uses poly(dT)·poly(rA) and poly(rA)·poly(rU) as templates but has little or no response to DNA or several single-stranded RNAs.

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Author notes

  1. D. C. WARD

    Present address: Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, 06510

  2. I. B. WEINSTEIN

    Present address: Institute of Cancer Research and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, 10032

Authors and Affiliations

  1. Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, WC2

    D. C. WARD, K. C. HUMPHRYES & I. B. WEINSTEIN

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  1. D. C. WARD
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  2. K. C. HUMPHRYES
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  3. I. B. WEINSTEIN
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WARD, D., HUMPHRYES, K. & WEINSTEIN, I. Synthetic RNA-dependent DNA Polymerase Activity in Normal Rat Liver and Hepatomas. Nature 237, 499–503 (1972). https://doi.org/10.1038/237499a0

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