Abstract
PYRAMIDAL CELLS are highly differentiated cortical neurones whose morphophysiological properties derive largely from dendritic systems that provide most of the postsynaptic sites for excitatory and inhibitory synaptic inputs1. As pyramidal cell function is closely linked to dendritic geometry2,3 factors influencing dendritic growth determine to a large extent connectivity patterns in cortical neuronal organisations4–6. Although various experimental manipulations hinder attainment of normal dendritic geometry7 no factors or conditions are known to induce dendritic growth and differentiation in intact, mature cortical neurones. I present here morphological evidence that in human ganglioside storage disease pyramidal neurones, having completed an initial period of normal dendritic growth, undergo a second phase of dendritic growth and differentiation at aberrant sites. I have referred to this in another context as ectopic dendrogenesis8.
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PURPURA, D. Ectopic dendritic growth in mature pyramidal neurones in human ganglioside storage disease. Nature 276, 520–521 (1978). https://doi.org/10.1038/276520a0
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DOI: https://doi.org/10.1038/276520a0
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