Abstract
ONE of the chief difficulties in the interpretation of the analogies between the biological activity of a drug and its behaviour in synthetic systems arises from the ambiguity of toxicological data, which may generally be correlated with solubility in the cell lipoids (Overton-Meyer), adsorption at cell interfaces (Traube), or with other physico-chemical factors. Moreover, these analogies may not hold when other biological systems and homologous series of drugs are compared. Recent work on molecular interaction in monolayers has provided a very valuable guide to the factors which influence specific drug reactivity in pharmacological systems1. The principles which have been advanced have greatly extended the implications of the original conceptions of Overton-Meyer and Traube.
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References
Schulman, J. H., and Rideal, E. K., Proc. Roy. Soc., B, 122, 29 (1937). Schulman, J. H., and Stenhagen, E., Proc. Roy, Soc., B. 126, 356 (1938). Schulman, J. H., and Rideal, E. K., NATURE, 144, 100 (1939).
Wigglesworth, V. B., "The Principles of Insect Physiology" (London: Methuen, 1939).
Hurst, H., NATURE, 145, 462 (1940); 147, 388 (1941).
Adam, N. K., "The Physics and Chemistry of Surfaces" (London, 1941).
Cockbain, E. G., and Schulman, J. H., Trans. Farad. Soc., 25, 716 (1939).
Campbell, F. L., Barnhart, C. S., and Hutzell, J. M., Soap and San. Chem., 17, No. 7, 105 (1940). Lowenstein, O., NATURE, 150, 760 (1942). Murray, C. A., Soap and San. Chem., 16, No. 6, 111 (1940). Parkin, E. A., NATURE, 149, 720 (1942).
Anon, "Soap and San. Chem. Blue Book", 184 (1942).
Ponder, E., J. Exp. Biol., 19, 220 (1942).
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HURST, H. PERMEABILITY AND MOLECULAR CONSTITUTION AS FACTORS IN DRUG ACTION. Nature 152, 292–296 (1943). https://doi.org/10.1038/152292a0
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DOI: https://doi.org/10.1038/152292a0
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