Abstract
A SPECIES of Cephalosporium has been found to produce two different kinds of antibacterial substance1,2. The first consists of a group of acidic antibiotics which are soluble in common organic solvents, are active mainly against Gram-positive organisms2, and show similarities to helvolic acid2–4. The second consists of a substance (or group of substances) which is insoluble in most organic solvents and is active against a number of Gram-positive and Gram-negative organisms. This has been called ‘cephalosporin N’. Evidence has now been obtained that cephalosporin N is a new type of penicillin.
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ABRAHAM, E., NEWTON, G., CRAWFORD, K. et al. Cephalosporin N: a New Type of Penicillin. Nature 171, 343 (1953). https://doi.org/10.1038/171343a0
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DOI: https://doi.org/10.1038/171343a0
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