Abstract
EVIDENCE that pyridoxal phosphate is involved in the synthesis of serine by micro-organisms has been provided by Lascelles and Woods1, who found that incorporation of pyridoxal phosphate in the medium stimulated serine synthesis by washed cells of Streptococcus faecalis R. and enabled Leuconostoc mesenteroides to grow in the presence of glycine and a CO2-rich atmosphere instead of serine. Participation of pyridoxal phosphate in serine synthesis in chickens was suggested by the observation that liver extracts from pyridoxine-deflcient chickens showed a reduced ability to incorporate [14C]formate into the β-position of serine2; but hitherto attempts to demonstrate a direct activation by pyridoxal phosphate of serine synthesis by liver extracts have been unsuccessful3.
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References
Lascelles, J., and Woods, D. D., Nature, 166, 649 (1950).
Deodhar, S., and Sakami, W., Fed. Proc., 12, 195 (1953).
Blakley, R. L., Biochem. J. (in the press).
Nash, T., Biochem. J., 55, 416 (1953).
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BLAKLEY, R. Participation of Pyridoxal Phosphate in the Enzymic Synthesis of Serine. Nature 174, 652 (1954). https://doi.org/10.1038/174652a0
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DOI: https://doi.org/10.1038/174652a0
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