Abstract
RECENT infectivity studies with partially degraded tobacco mosaic virus have led to the inference that the virus particles can remain active after some of the protein has been experimentally removed so as to expose portions of the ribonucleic acid core1,2. In one of these studies2 it was found that, upon heating the virus briefly with a detergent, the infectivity was reduced from that in the original sample by a factor of 4–10; most of the activity then remaining was found to reside in partially degraded virus particles, as judged by the fact that their infectivity could be greatly reduced by digestion with crystalline pancreatic ribonuclease.
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References
Schramm, G., Schumacher, G., and Zillig, W., Nature, 175, 495 (1955).
Hart, R. G., Virology, [1, 402 (1955)].
Fraenkel-Conrat, H., and Williams, R. C., Proc. U.S., Nat. Acad. Sci., [41, 690 (1955)].
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HART, R. Reactivation of Partially Degraded Tobacco Mosaic Virus. Nature 177, 130–131 (1956). https://doi.org/10.1038/177130b0
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DOI: https://doi.org/10.1038/177130b0
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