Abstract
A SIGNIFICANT contribution is achieved by Drs. Armitage, Court Brown and Doll in evaluating some models postulated in assessing the leukæmogenic potency of radiations. Along this line, it appears relevant to discuss some possible interpretations of a linear dose-response, observed over a limited range of leukæmia incidence, as evidenced in the study of patients irradiated for ankylosing spondilytis. Basic assumptions of some theoretical models will be first examined.
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Armitage, P., and Spicer, C. C., J. Hyg. (Camb.), 54, 401 (1956).
Court Brown, W. M., and Doll, R., Spec. Rep. Ser. Med. Res. Counc. London, NO. 295 (1957).
Kaplan, H. S., and Brown, M. B., J. Nat. Cancer Inst., 13, 185 (1952).
Upton, A. C., and Furth, J., Proc. Third Nat. Cancer Conf. Philadelphia and Montreal (J. B. Lippincott Company, 1957).
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MEWISSEN, D. Dose-Response Relationship in Radiation Leukæmia. Nature 184, 1670 (1959). https://doi.org/10.1038/1841670a0
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DOI: https://doi.org/10.1038/1841670a0
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