Abstract
IT is known that rats and other animals injected with nervous tissue emulsified in Freund's adjuvant may develop allergic encephalomyelitis within 2–3 weeks1–3. Many of the injected animals, irrespective of whether they develop encephalomyelopathy, produce complement-fixing antibodies which specifically react in vitro with homologous or heterologous brain extracts4–8. The role of these complement-fixing anti-brain antibodies, however, in the pathogenesis of allergic encephalomyelitis remains unknown.
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HARWIN, S., PATERSON, P. & DIDAKOW, N. Antibodies against Autologous Brain in Rats with Allergic Encephalomyelitis. Nature 189, 322–323 (1961). https://doi.org/10.1038/189322a0
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DOI: https://doi.org/10.1038/189322a0
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