Abstract
THIS Laboratory is examining the chemistry of ‘gastrin’, about which little has been reported. We have recently prepared a gastrin-like secretory stimulant from porcine antral mucosa by a new and somewhat novel method. This is a preliminary report on its chemical properties, and similar data on ‘gastrin’ as prepared by a more conventional procedure. The quotation marks signify only that it is not known whether gastrin is a single compound, or a group of similar structures with a common unique moiety, or a group of biologically, more or less, specific substances. The facts that gastrin has been reported as dialysable1, non-dialysable2, with an isoelectric point near pH 5.03, or pH 8.04, to name only a few of its properties, leave the question very much open. Recently, Gregory et al. 5 described a gastrin-like substance isolated from a pancreatic tumour.
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Babkin, B. P., Secretory Mechanism of the Digestive Glands, second ed., 485 (Paul B. Hoeber, Inc., New York, 1950).
Babkin, B. P., Secretory Mechanism of the Digestive Glands, second ed., 487 (Paul B. Hoeber, Inc., New York, 1950).
Uvnäs, B., Acta Physiol. Scand., 9, 296 (1945).
Spector, W. S., Handbook of Biological Data, 384 (W. B. Saunders, Philadelphia, 1956).
Gregory, R. A., Tracy, H. J., French, J. M., and Sircus, W., Lancet, 1045 (1960).
Perlmann, G. E., in Adv. in Protein Chem., edit. by Anson, M. L., Bailey, K., and Edsall, J. T., 10, 1 (1955).
Feigl, F., Spot Tests in Organic Analysis, fifth ed., 401 (Elsevier, Amsterdam, 1956).
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FLETCHER, T., ANDERSON, W., PITTS, C. et al. A New Preparation of Gastrin: Preliminary Characterization. Nature 190, 448 (1961). https://doi.org/10.1038/190448a0
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DOI: https://doi.org/10.1038/190448a0
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