Abstract
HALOPERIDIDE, the proposed generic name for 4′-fluoro-(4-(4′-pyrrolidin-amido-4′-m-chlorophenyl)-piperidino)-butyrophenone (serial number R 3201), was synthesized in the Organic Chemistry Department of this Laboratory. It is a new member of the butyrophenone series of neuroleptic compounds (Fig. 1). The prototype of this series, haloperidol (R 1625), has been described in a number of pharmacological and clinical publications. It has been shown that haloperidol is pharmacologically related to the potent neuroleptics of the phenothiazine-series1–6.
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JANSSEN, P., NIEMEGEERS, C. Haloperidide (R3201), a Highly Potent and Selective Anti-emetic Agent in Dogs. Nature 190, 911–912 (1961). https://doi.org/10.1038/190911a0
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DOI: https://doi.org/10.1038/190911a0
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