Abstract
Laqueur, Dingemanse, Hart and de Jongh1 first reported in 1927 that œstrogenically active substances could be obtained from the urine of healthy men. The necessity arose shortly afterwards of identifying these active substances chemically. The small amounts in which these active substances occur in adult male urine has so far made this impossible. Dorfman, Gallagher and Koch2 tried to solve the problem in 1935 by means of comparative biological studies, but such investigations merely produced indications as to the nature of the Å"strogenically active substance.
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DINGEMANSE, E., LAQUEUR, E. & MÜHLBOCK, O. Chemical Identification of CEstrone in Human Male Urine. Nature 141, 927 (1938). https://doi.org/10.1038/141927a0
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DOI: https://doi.org/10.1038/141927a0
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