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Transplantation tolerance: babies take the first step

Nature Medicine volume 10, pages 1165–1166 (2004)Cite this article

Babies will accept transplants from donors of different blood groups, a situation that is catastrophic in adults. The basis for this acceptance is now examined and found to hinge on B-cell tolerance (pages 1227–1233).

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Figure 1: Tolerance then and now.

Michael Pace

References

  1. Billingham, R.E., Brent, L. & Medawar, P.B. Nature 172, 603–606 (1953).

    Article  CAS  Google Scholar 

  2. Fan, X. et al. Nat. Med. 10, 1227–1233 (2004).

    Article  CAS  Google Scholar 

  3. Porter, K. et al. Br. Med. J. 5358, 639–645 (1963).

    Article  Google Scholar 

  4. Fong, S., Qaqundah, B. & Taylor, W. Transfusion 14, 551–559 (1974).

    Article  CAS  Google Scholar 

  5. West, L. et al. N. Engl. J. Med. 344, 793–800 (2001).

    Article  CAS  Google Scholar 

  6. Ridge, J.P., Fuchs, E.J. & Matzinger, P. Science 271, 1723–1726 (1996).

    Article  CAS  Google Scholar 

  7. Sarzotti, M., Robbins, D.S. & Hoffman, P.M. Science 271, 1726–1728 (1996).

    Article  CAS  Google Scholar 

  8. Forsthuber, T., Yip, H. & Lehmann, P. Science 271, 1728–1730 (1996).

    Article  CAS  Google Scholar 

  9. Gathings, W., Kubagawa, H. & Cooper, M. Immunol. Rev. 57, 107–126 (1981).

    Article  CAS  Google Scholar 

  10. Springer, G.F. & Horton, R.E. J. Clin. Invest. 48, 1280–1291 (1969).

    Article  CAS  Google Scholar 

  11. Zinkernagel, R.M. & Hengartner, H. Science 293, 251–253 (2001).

    Article  CAS  Google Scholar 

  12. Owen, R.D. Science 102, 400–401 (1945).

    Article  CAS  Google Scholar 

  13. Starzl, T. Proc. Natl. Acad. Sci. USA 101, 14607–14614 (2004).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Section of Nephrology (Department of Internal Medicine) and the Section of Immunobiology, Yale University School of Medicine, New Haven, 06511, Connecticut, USA

    Jagdeep S Obhrai & Fadi G Lakkis

Authors
  1. Jagdeep S Obhrai
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  2. Fadi G Lakkis
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Obhrai, J., Lakkis, F. Transplantation tolerance: babies take the first step. Nat Med 10, 1165–1166 (2004). https://doi.org/10.1038/nm1104-1165

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