Summary
After experimental intoxication of rats, gas chromatography — Fourier transform infrared spectrometry with headspace sampling (HS/GC/FT-IR) was used to identify solvents of abuse in biological material (blood, liver, lungs and brain). Limits of detection were measured for acetone, 2-butanone, ether, toluene and trichlorethylene with standard solutions. All the solvents have been identified in the organs of the intoxicated rats. For blood samples a salting-out effect was obtained with potassium carbonate. HS/GC/FT-IR allowed the identification of metabolites of acetone (isopropanol) and of 2-butanone (2-butanol) in blood and organs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. Deveaux, J. P. Huvenne, Trends Anal. Chem.4, 149 (1985).
M. Deveaux, B. Lacroix, M. T. Romon, J. P. Huvenne, Inn. Tech. Biol. Med.7, 99 (1986).
M. Deveaux, Thesis. Lille (1987).
H. Hachenberger, A. P. Schmidt, “Gas chromatography Headspace analysis”, Heyden, London (1977).
J. D. Ramsey, R. J. Flanagan, J. Chromatogr.240, 423 (1982).
L. Perbellini, R. Leone, M. E. Francasso, F. Brungnone, M. S. Venturini, Int. Arch. Occup. Environ. Health50, 351 (1982).
J. S. Oliver, J. M. Watson, Lancet i, 84 (1977).
W. Vierke, J. Gellert, R. Teschke, Arch. Toxicol51, 91 (1982).
G. Merlot, B. Lacroix, M. T. Romon, J. P. Huvenne, G. Fleury, Talanta33, 299 (1986).
S. R. Lowry, D. A. Huppler, Anal. Chem.53, 889 (1981).
G. D. Lewis, A. K. Laufman, B. H. McAnnaley, J. C. Garriot, J. Forensic Sci.29, 541 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Deveaux, M., Huvenne, J.P. Identification of solvents of abuse using gas chromatography/Fourier transform infrared spectrometry after headspace sampling. Chromatographia 23, 626–630 (1987). https://doi.org/10.1007/BF02311489
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02311489