Skip to main content
SpringerLink
Log in

Vitamin A and ciliated cells I. Respiratory epithelia

  • Original Contributions
  • Published:
Zeitschrift für Ernährungswissenschaft Aims and scope Submit manuscript

Summary

To estimate the role of vitamin A on ciliated cells we investigated whether ciliated cells undergo any alteration during vitamin A deficiency. The epithelia examined include the ciliated cells of the respiratory tract and the ciliated sensory cells of the inner ear, the tongue, and the olfactory cells. This part of the paper will describe the ciliated epithelium of the tracheobronchial tract and its relation to vitamin A status. During vitamin A deficiency a partial loss of ciliae can be observed before any squamous metaplasia (which usually occurs during longer lasting vitamin A deficiency) develops. The scanning electron microscopic data illustrate the altered surface of the epithelium during vitamin A deficiency better than transmission electron microscopy.

Zusammenfassung

Um zu prüfen, in welcher Weise Vitamin A zilientragende Epithelien beeinflußt, wurde untersucht, ob zilientragende Epithelien im Vitamin-A-Mangel besondere Veränderungen aufweisen. Die untersuchten Gewebe beinhalten das Respirationsepithel sowie die zilientragenden Sinnesepithelien des Innenohres, der Zunge und des Riechepithels. Dieser Teil beschreibt die Veränderungen des zilientragenden Epithels des Tracheobronchialtraktes in Relation zum Vitamin-A-Status. Mit rasterelektronenmikroskopischen Methoden konnte im Vitamin-A-Mangel ein fleckiger Verlust von Zilien des Respirationsepithels beobachtet werden, bevor es zu einer squamösen Metaplasie des Gewebes — wie sie im Vitamin-A-Mangel beschrieben ist — kam. Die rasterelektronenmikroskopischen Aufnahmen stellen die Veränderungen an den zilientragenden Zellen dieses Epithels anschaulicher dar, als dies mit transmissionselektronenmikroskopischen Verfahren möglich ist.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vinnikov JA (1965) Principles of structural, chemical and functional organization of sensory receptors. Cold Spring harbor Symposium: Quant Biol 30:243

    Article  Google Scholar 

  2. Biesalski HK (1984) Retinol and Retinyl ester in separated structures of the guinea-pig inner ear. Internat J Vit Nutr Res 54:113

    CAS  Google Scholar 

  3. Biesalski HK (1985) Aspects of vitamin A metabolism in sensory epithelia. Internat J Vit Nutr Res Suppl 27:225

    CAS  Google Scholar 

  4. Hof H (1976) Vitamin A, das „Anti-Infektive“ Vitamin. Münch Med Wochenschr 118:1485

    CAS  Google Scholar 

  5. McLaren DS (1966) Present knowledge of the role of vitamin A in health and disease. Trans R Soc Trop Med Hyg 60:436

    Article  CAS  Google Scholar 

  6. Anzano Ma, Olson JA, Lamb AJ (1980) Morphologic alterations in the trachea and the salivary gland following the induction of a rapid synchronous vitamin A deficiency in rats. Am J Pathol 98:717

    CAS  Google Scholar 

  7. Chopra DP (1982) Squamous metaplasia in organ cultures of vitamin A deficient hamster trachea: Cytokinetic and ultrastructural alterations. J Natl Cancer Inst 69:895

    CAS  Google Scholar 

  8. Ito S, Karnovsky HJ (1968) Formaldehyde-Glutaraldehyde fixatives containing trinitro compounds. J Cell Biol 39:168a

    Google Scholar 

  9. Hilding DA, Hilding AC (1966) Ultrastructure of tracheal cilia and cells during regeneration. Ann Otol 75:281

    Google Scholar 

  10. Cireli E (1966) Elektronenmikroskopische Analyse der prä- und postnatalen Differenzierung des Epithels der oberen Luftwege der Ratte. Zeitscher f mikr anat Forsch 74:133

    Google Scholar 

  11. Kolipost G (1981) Die Bedeutung der Autolyse für die REM-Untersuchung von Operationsund Leichenmaterial dargelegt am Beispiel der Trachealschleimhaut der Ratte. Inaugural-Dissertation, Mainz

  12. McDowell EM, Keenan KP, Huang M (1984) Effects of vitamin A deprivation on hamster tracheal epithelium. Virchows Arch Cell Pathol 45:197

    Article  CAS  Google Scholar 

  13. Dahlgreen SE, Dalen H (1972) Ultrastructural observation on the chemically induced inflammation in guinea-pig trachea. Virchows Arch Cell Pathol 11:211

    Google Scholar 

  14. Greenwood MF, Holland P (1972) The mammalian respiratory tract surface. Lab Invest 27:296

    CAS  Google Scholar 

  15. Wolbach SB, Howe PR (1928) Vitamin A deficiency in the guinea-pig. Arch Pathol 5:239

    CAS  Google Scholar 

  16. Wong YC, Buck RC (1971) An electron microscopic study of the metaplasia of the rat tracheal epithelium in vitamin A deficiency. Lab Invest 24:55

    CAS  Google Scholar 

  17. Harris CC, Silverman T, Smith JM, Jackson F, Boren HG (1974) Proliferation of tracheal epithelial cells in normal and vitamin A deficient Syrian hamsters. J Natl Cancer Inst 51:1059

    Article  Google Scholar 

  18. Boren HG, Pauly J, Wright EC, Kaufman DG, Smith JM, Harris CC (1974) Cell population in the hamster tracheal epithelium in relation to vitamin A status. Int J Vit Nutr Res 44:382

    CAS  Google Scholar 

  19. Chopra DP (1983) Cell dynamics in explants derived from tracheas of hamsters fed normal and vitamin A deficient diets. Cell Tissue Kinet 16:155

    CAS  Google Scholar 

  20. Wilhelm DL (1954) Regeneration of the tracheal epithelium in the vitamin A deficient rat. J Path Bact 67:361

    Article  CAS  Google Scholar 

  21. Auerbach O, Stout AP, Hammond EC, Garfinkel L (1961) Changes in bronchial epithelium in relation to cigarette smoking and relation to lung cancer. New Engl J Med 265:253

    Article  CAS  Google Scholar 

  22. Nettesheim P, Griesemer RA (1978) Experimental models for studies of respiratory tract carcinogenesis. In Harris CC (ed) Pathogenesis and therapy of lung cancer. Marcel Dekker Inc New York

    Google Scholar 

  23. Harris CC, Sporn MB, Kaufmann DG, Smith JM, Baker MS, Saffioti U (1971) Acute ultrastructural effects of benzo(a)pyrene ferric oxide on the hamster tracheobronchial epithelium. Cancer Res 31:1977

    CAS  Google Scholar 

  24. Harris CC, Sporn MB, Kaufman DG, Smith JM, Baker MS, Affioti U (1972) Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo(a)pyrene ferric oxide. J Natl Cancer Inst 48:743

    CAS  Google Scholar 

  25. Sporn MB, Clamon GH, Dunlop NM, Newton DL, Smith JM, Saffioti U (1975) Activity of vitamin A analogues in cell cultures of mouse epidermis in organ cultures of hamster trachea. Nature 253:47

    Article  CAS  Google Scholar 

  26. Kaufman DG, Baker MS, Smith JM, Henderson WR, Harris CC, Sporn MB (1972) RNA metabolism in tracheal epithelium. Alterations in hamsters deficient in vitamin A. Science 177:105

    Article  Google Scholar 

  27. Aydelotte MB (1963) The effects of vitamin A and citral on epithelial differentiation in vitro. I The chick tracheal epithelium. J Embryol Exptl Morphol 11:279

    CAS  Google Scholar 

  28. Crocker TT, Sanders LL (1970) Influence of vitamin A and 3,7-dimethyl-2,6-octadienal (Citral) on the effect of benzo(a)pyrene on hamster tracheal organ culture. Cancer Res 30:1312

    CAS  Google Scholar 

  29. Santa CR, Sand J, Hirsch J, Sackner MA (1974) Tracheal mucous velocity in normal man and patients with obstructive lung disease; effects of terbutaline. Am Rev Resp Dis 109:458

    Google Scholar 

  30. Woodruff KH, Schneider E, Unger L, Coalson JJ (1973) Ultrastructural changes in hamster tracheal ring cultures exposed to mycoplasma pneumoniae. Am J Pathol 72:91

    CAS  Google Scholar 

  31. Reimer A, Mecklenburg C, Toremalm MG (1978) The mucociliary activity of the upper respiratory tract. Acta otolaryng Suppl 355

  32. Hilding AC (1964) Mucociliary insufficiency and its possible relation to chronic bronchitis and emphysema. In: Mitchell RS (ed) Progress in research in emphysema and chronic bronchitis. Karger, Basel

    Google Scholar 

  33. Hartung W, Kissler W, Teige K, Thoma H (1971) Pathologisch-anatomische Folgen chronischer Bronchitis und deren Beziehung zur Lungenfunktion. Progr Resp Res 6:108

    Article  Google Scholar 

  34. Ohashi Y, Nakai Y (1984) Mucociliary activities in fetal rabbits. Acta otolaryng 95:351

    Article  Google Scholar 

  35. Winther B, Brofeldt B, Christensen B, Nygind M (1984) Light- and scanning electron microscopy of nasal biopsy material from patients with naturally acquired common colds. Acta otolaryng 97:309

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. H. K. Biesalski

    Present address: Physiologisch-Chemisches Institut der Universität Mainz, Mainz, F.R.G.

Authors and Affiliations

  1. Physiologisch-Chemisches Institut der Universität Mainz, Mainz, F.R.G.

    K. H. Bässler

  2. Anatomisches Institut der Universität Mainz, Mainz, F.R.G.

    E. Stofft, U. Wellner & U. Niederauer

Authors
  1. H. K. Biesalski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Stofft
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. Wellner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. U. Niederauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. H. Bässler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Biesalski, H.K., Stofft, E., Wellner, U. et al. Vitamin A and ciliated cells I. Respiratory epithelia. Z Ernährungswiss 25, 114–122 (1986). https://doi.org/10.1007/BF02020741

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02020741

Key words

Search

Navigation