Abstract
A mathematical model of prothrombin activation is being proposed which includes the feedback mechanism of thrombin and the alteration of factor V by thrombin. This model is in good agreement with experimental data for the dependence of the rate of thrombin formation on the concentrations of factors V and X a . In particular, it correctly predicts the existence and location of a maximum in both of these cases.
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Liniger, W., Karreman, G., Rawala, R. et al. Mathematical model of the activation of prothrombin by factor X a and factor V t . Bltn Mathcal Biology 42, 861–870 (1980). https://doi.org/10.1007/BF02461064
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DOI: https://doi.org/10.1007/BF02461064