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Evolution and sequence analysis of a human Y-chromosomal DNA fragment

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Summary

A Y-chromosomal DNA fragment has been isolated from a human Y-Charon 21A recombinant library. Evolutionary analysis of 1F5 indicates that the size and sequence of this fragment have been conserved in higher primates. Deletion mapping and in situ hybridization analysis have localized 1F5 to the middle euchromatic portion of the long arm of the human Y chromosome at Yq11.2. Sequence analysis revealed the presence of an atypical Alu element and two regions rich in polypyrimidine-polypurine residues.

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Authors and Affiliations

  1. Departments of Structural & Cellular Biology, and Medical Genetics, University of South Alabama, College of Medicine, 36688, Mobile, AL, USA

    E. C. Whisenant, B. K. A. Rasheed & Y. M. Bhatnagar

  2. Division of Genetics, Department of Pediatrics, University of Florida, College of Medicine, 32610, Gainesville, FL, USA

    H. Ostrer

Authors
  1. E. C. Whisenant
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  2. B. K. A. Rasheed
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  3. H. Ostrer
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  4. Y. M. Bhatnagar
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Whisenant, E.C., Rasheed, B.K.A., Ostrer, H. et al. Evolution and sequence analysis of a human Y-chromosomal DNA fragment. J Mol Evol 33, 133–141 (1991). https://doi.org/10.1007/BF02193627

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  • DOI: https://doi.org/10.1007/BF02193627

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