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Some evidence for the universality of structural periodicity in proteins

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Summary

A new simple and sensitive method for detecting small periodicity (repetition of a small segment along the chain) in proteins is developed, based on the repetition of identical residues. 38 proteins from organisms representing different levels of evolutionary development have been tested for small periodicity. The same is done with the nodal ancestors of 25 of them. The results are presented graphically (the periodicity curves). The statistical signficance of the observed periodicity is confirmed by a modified version of the chi-square test. All the results obtained support the conception that the small periodicity of the contemporary proteins is a reflection of their evolutionary history and that the most ancient proteins have arisen through a polycondensation of short peptides or through transcription and translation of satellite-type repeat sequence DNA.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Orlin C. Ivanov

  2. Department of Organic Chemistry, Higher Institute of Chemical Technology, 1156, Sofia, Bulgaria

    Chavdar P. Ivanov

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  1. Orlin C. Ivanov
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  2. Chavdar P. Ivanov
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Ivanov, O.C., Ivanov, C.P. Some evidence for the universality of structural periodicity in proteins. J Mol Evol 16, 47–68 (1980). https://doi.org/10.1007/BF01732069

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  • DOI: https://doi.org/10.1007/BF01732069

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