Skip to main content

Advertisement

Log in

Oxalic acid metabolism in man: A review

  • Review
  • Published:
Calcified Tissue Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Albuquerque, P. F., andM. Tuma: Investigations on urolithiasis. II. Studies on oxalate J. Urol. (Baltimore)87, 504–506 (1961).

    Google Scholar 

  • Andrews, J. C., andE. T. Viser: The oxalic acid content of some common foods. Food Res.16, 306–312 (1951).

    Google Scholar 

  • Andrus, S. B., S. N. Gershoff, F. F. Faragalla, andE. L. Prien: Production of calcium oxalate renal calculi in vitamin B6-deficient rats. Lab. Invest.9, 7–27 (1960).

    PubMed  Google Scholar 

  • Archer, H. E., A. E. Dormer, E. F. Scowen, andR. W. E. Watts: Studies on the urinary excretion of oxalate by normal subjects. Clin. Sci.16, 405–411 (1957).

    PubMed  Google Scholar 

  • ————: The aetiology of primary hyperoxaluria. Brit. med. J.I, 175–181, 1958.

    Google Scholar 

  • Atkins, G. L., B. M. Dean, W. J. Griffin, andR. W. E. Watts: Quantitative aspects of ascorbic acid metabolism in man. J. biol. Chem.239, 2975–2980 (1964).

    PubMed  Google Scholar 

  • Baker, E. M., H. E. Sauberlitch, S. J. Wolfskill, W. T. Wallace, andE. E. Dean: Tracer studies of vitamin C utilisation in men: metabolism of D-glucuronolactone-6-14C, D-glucuronic-6-14C acid and L-ascorbic-I-14C acid. Proc. Soc. exp. Biol. (N.Y.)109, 737–741 (1962).

    Google Scholar 

  • Barber, H. H., andE. J. Gallimore: The metabolism of oxalic acid in the animal body. Biochem. J.34, 144–148 (1940).

    Google Scholar 

  • Barrett, J. F. B.: The oxalate content of blood. Biochem. J.37, 254–256 (1943).

    Google Scholar 

  • Bennett, B., andC. Rosenblum: Identification of calcium oxalate crystals in the myocardium in patients with uremia. Lab. Invest.10, 947–955 (1961).

    Google Scholar 

  • Bennington, J. L., S. L. Haber, J. V. Smith, andN. E. Warner: Crystals of calcium oxalate in the human kidney. Amer. J. clin. Path.41, 8–14 (1964).

    Google Scholar 

  • Bove, K. E.: Ethylene glycol toxicity. Amer. J. clin. Path.45, 46–50 (1966).

    Google Scholar 

  • Carter, H. E., P. Johnson, D. W. Teets, andR. K. Yu: Isolation of ethylene glycol from the lipids of beef lung. Biochem. biophys. Res. Commun.13, 156–161 (1963).

    Article  Google Scholar 

  • Cattell, W. R., A. G. Spencer, G. W. Taylor, andR. W. E. Watts: The mechanism of the renal excretion of oxalate in the dog. Clin. Sci.22, 43–52 (1962).

    PubMed  Google Scholar 

  • Cochran, M., A. Hodgkinson, P. M. Zarembski andC. K. Anderson: Hyperoxaluria in adults. Brit. J. Surg.55, 121–128 (1968).

    PubMed  Google Scholar 

  • Cogan, D. G., J. Kuwabara, T. Silbert, H. Kern, V. McMurray, andC. Hurlburt: Calcium oxalate crystals in detached retinas. Arch. Opthal.60, 366–371 (1958).

    Google Scholar 

  • Constantin, L. L., C. Franzini-Armstrong, andR. J. Podolsky: Localization of calciumaccumulating structures in striated muscle fibers. Science (N.Y.)147, 158–160 (1965).

    Google Scholar 

  • —, andL. W. Tice: Calcium activation of frog slow muscle fibres. J. Physiol. (Lond.)188, 261–271 (1967).

    Google Scholar 

  • Cottet, J., etCh. Vittu: Oxalurie, lithiases urinaires et regime alimentaire. Presse méd.74, 1759–1763 (1966).

    Google Scholar 

  • ——, etJ. Lemahieu: Oxalurie et lithiases urinaires J. Urol. Néphrol.71, 1076–1080 (1965).

    Google Scholar 

  • Crawhall, J. C., R. R. de Mowbray, E. F. Scowen, andR. W. E. Watts: Conversion of glycine to oxalate in a normal subject. Lancet1959 II, 810.

  • —, andR. W. E. Watts: The oxalate content of human plasma. Clin. Sci.20, 357–366 (1961).

    PubMed  Google Scholar 

  • Curtin, C. O., andC. G. King: The metabolism of ascorbic acid-1-14C and oxalic acid-14C in the rat. J. biol. Chem.216, 539–548 (1955).

    PubMed  Google Scholar 

  • Daniels, R. A., R. Michels, P. Aisen, andG. Goldstein: Familial hyperoxyluria. Report of a family, Review of the literature. Amer. J. Med.29, 820–831 (1960).

    Article  PubMed  Google Scholar 

  • Dean, B. M., andW. J. Griffin: Estimation of urinary oxalate by the method of isotope dilution. Nature (Lond.)205, 598–599 (1965).

    Google Scholar 

  • Dempsey, E. F., A. P. Forbes, R. A. Melick, andP. H. Henneman: Urinary oxalate excretion. Metabolism9, 52–58 (1960).

    PubMed  Google Scholar 

  • De Vries, A., S. Kochwa, J. Lazebnik, M. Frank, andM. Djaldetti: Glycinuria, a hereditary disorder associated with nephrolithiasis. Amer. J. Med.23, 408–415 (1957).

    Article  PubMed  Google Scholar 

  • Dodds, E. C., andE. J. Gallimore: Determination of small quantities of oxalic acid. Biochem. J.26, 1242–1245 (1932).

    Google Scholar 

  • Dodson, M. E.: Oxalate ingestion studies in the sheep. Aust. vet. J.35, 225–233 (1959).

    Google Scholar 

  • Donne, M. A.: Tableau de differents depots de matieres salines et de substance organisees qui se font dans les urines, presentent les caracteres propre a les distinguer entre eux et a reconnaitre leure nature. C. R. Acad. Sci. (Paris)1, 419 (1838).

    Google Scholar 

  • Dunn, J. S., A. Haworth, andN. A. Jones: The pathology of oxalate nephritis. J. Path. Bact.27, 299–318 (1924).

    Article  Google Scholar 

  • Dyer, R., andB. E. C. Nordin: Urinary crystals and their relation to stone formation. Nature (Lond.)215, 751–752 (1967).

    Google Scholar 

  • Eegriwe, E.: Reactionen und Reagenzien, zum Nachweis organischer Verbindungen. Z. anal. Chem.110, 22–25 (1937).

    Google Scholar 

  • Eisenstein, R., R. E. Trueheart, andG. M. Hass: Chapter in: Calcification in biological systems (ed.R. F. Sognnaes), p. 281 f. f. Washington. Amer. Ass. Advanc. Sci. 1960.

    Google Scholar 

  • Elder, T. D., andJ. B. Wyngaarden: The biosynthesis and turnover of oxalate in normal and hyperoxaluric subjects. J. clin. Invest.39, 1337–1344 (1960).

    PubMed  Google Scholar 

  • Elliot, J. S.: Calcium stones: The difference between oxalate and phosphate types. J. Urol. (Baltimore) (1968) (in press).

  • —, andE. Eusebio: Calcium oxalate solubility: The effect of inorganic salts, urea, creatinine and organic acids. Invest. Urol.3, 72–76 (1965).

    Google Scholar 

  • Emerson, P. M., andJ. H. Wilkinson: Urea and oxalate inhibition of the serum lactate dehydrogenase. J. clin. Path.18, 803–807 (1965).

    PubMed  Google Scholar 

  • Evans, R. A., M. A. Forbes, R. A. L. Sutton, andL. Watson: Urinary excretion of calcium and magnesium in patients with calcium-containing renal stones. Lancet1967 II, 958–961.

  • Faber, S. R., W. W. Feitler, R. E. Bleiler, M. A. Ohlson, andR. E. Hodges: The effects of an induced pyridoxine and pantothenic acid deficiency on excretion of oxalic and xanthurenic acids in the urine. Amer. J. clin. Nutr.12, 406–412 (1963).

    Google Scholar 

  • Fanburg, B., andJ. Gergely: Studies on adenosine triphosphate-supported calcium accumulation by cardiac subcellular particles. J. biol. Chem.240, 2721–2728 (1965).

    PubMed  Google Scholar 

  • Fanger, H., andA. Esparza: Crystals of calcium oxalate in kidneys in uremia. Amer. J. clin. Path.41, 597–603 (1964).

    Google Scholar 

  • Fleisch, H.: Some new concepts on the pathogenesis and the treatment of urolithiasis. Urol. int. (Basel)19, 372–389 (1965).

    Google Scholar 

  • —, andS. Bisaz: The inhibitory effect of pyrophosphate on calcium oxalate precipitation and its relation to urolithiasis. Experientia (Basel)20, 276–277 (1964).

    Google Scholar 

  • Frederick, E. W., M. T. Rabkin, R. H. Richie, andL. H. Smith: Studies on primary hyperoxaluria I. In vivo demonstration of a defect in glyoxylate metabolism. New Engl. J. Med.269, 821–829 (1963).

    PubMed  Google Scholar 

  • Fujita, T., H. Orimo, M. Yoshikawa, H. Morii, andK. Nakao: Effects of acidosis and alkalosis on recovery from hypocalcemia. Endocrinology76, 1202–1204 (1965).

    PubMed  Google Scholar 

  • Gatter, R. A., andD. J. McCarty: Pathological tissue calcifications in man. Arch. Path.84, 346–353 (1967).

    Google Scholar 

  • Gerritsen, T., E. Kaveggia, andH. A. Waisman: A new type of idiopathic hyperglycinemia with hypo-oxaluria. Pediatrics36, 882–891 (1965).

    PubMed  Google Scholar 

  • Gershoff, S. N., F. F. Faragalla, D. A. Nelson, andS. B. Andrus: Vitamin B6 deficiency and oxalate nephrocalcinosis in the cat. Amer. J. Med.27, 72–80 (1959).

    Article  PubMed  Google Scholar 

  • —, andE. L. Prien: Effect of daily MgO and vitamin B6 administration to patients with recurring calcium oxalate kidney stones. Amer. J. clin. Nutr.20, 393–399 (1967).

    PubMed  Google Scholar 

  • Gessner, P. K., D. V. Parke, andR. T. Williams: Studies in detoxication 86. The metabolism of14C-labelled ethylene glycol. Biochem. J.79, 482–489 (1961).

    PubMed  Google Scholar 

  • Gibbs, D. A., andR. W. E. Watts: Biochemical studies on the treatment of primary hyperoxaluria. Arch. Dis. Childh.42, 505–508 (1967).

    PubMed  Google Scholar 

  • Glynn, L. E.: Crystalline bodies in tunica media of middle cerebral artery. J. Path. Bact.51, 445–446 (1940).

    Article  Google Scholar 

  • Gross, E. G.: Inorganic salt metabolism III. Inorganic ion ratio after administration of oxalates and citrates. J. biol. Chem.55, 729–738 (1923).

    Google Scholar 

  • Gross, S.: Granulomatous thyroiditis with anisotropic crystalline material. Arch. Path.59, 412–418 (1955).

    Google Scholar 

  • Grossmann, W.: The current urinary stone wave in Central Europe. Brit. J. Urol.10, 46–54 (1938).

    Google Scholar 

  • Hammarsten, G.: Chapter in: Etiologic factors in renal lithiasis (ed.A. J. Butt), p. 89. Springfield (Ill.): Ch. C. Thomas 1956.

    Google Scholar 

  • Hasselbach, W., u.M. Makinose: Die Calciumpumpe der Erschlaffungsgrane des Muskels und ihre Abhängigkeit von der ATP-Spaltung. Biochem. Z.333, 518–528 (1961).

    PubMed  Google Scholar 

  • Hausman, E. R., J. S. McAnally, andG. T. Lewis: Determination of oxalate in urine. Clin. Chem.2, 439–444 (1956).

    PubMed  Google Scholar 

  • Hellman, L. andJ. J. Burns: Metabolism ofl-ascorbic acid 1-14C in man. J. biol. Chem.230, 923–930 (1958).

    PubMed  Google Scholar 

  • Hockaday, T. D. R., J. E. Clayton, E. W. Frederick, andL. H. Smith: Primary hyperoxaluria Medicine (Baltimore)43, 315–345 (1964).

    Google Scholar 

  • —,E. W. Frederick, J. E. Clayton, andL. H. Smith: Studies on primary hyperoxaluria II. Urinary oxalate, glycolate and glyoxylate measurement by isotope dilution methods. J. Lab. clin. Med.65, 677–687 (1965).

    PubMed  Google Scholar 

  • Hodgkinson, A.: The urinary excretion of oxalic acid in nephrolithiasis. Proc. roy. Soc. Med.51, 970–971 (1958).

    PubMed  Google Scholar 

  • —, andP. M. Zarembski: The determination of oxalic acid in urine. Analyst86, 16–21 (1961).

    Article  Google Scholar 

  • Hoover, A. A., andM. C. Karunairatnam: Oxalate content of some leafy green vegetables and its relation to oxaluria and calcium utilization. Biochem. J.39, 237–238 (1945).

    Google Scholar 

  • Howard, J. E., W. C. Thomas, L. M. Barker, L. H. Smith, andC. L. Wadkins: The recognition and isolation from urine and serum of a peptide inhibitor to calcification. Johns Hopk. med. J.120, 119–136 (1967).

    Google Scholar 

  • Jeghers, H., andR. Murphy: Practical aspects of oxalate metabolism. New Engl. J. Med.233, 208–215, 238–246 (1945).

    Google Scholar 

  • Jurgens, R., u.G. Spehr: Zur Physiologie und Pathologie des Oxalsäurestoffwechsels. Dtsch. Arch. klin. Med.174, 456–467 (1933).

    Google Scholar 

  • Kagawa, Y.: Enzymatic studies on ascorbic acid catabolism in animals I. Catabolism of 2,3 diketol-gulonic acid. J. Biochem. (Tokyo)51, 134–144 (1962).

    Google Scholar 

  • Kalliala, H., andO. Kauste: Ingestion of rhubarb leaves as cause of oxalic acid poisoning. Ann. Paediat. Fenn.10, 228–231 (1964).

    PubMed  Google Scholar 

  • Kobert, R., u.B. Kussner: Die experimentellen Wirkungen der Oxalsäure. Virchows Arch. path. Anat.78, 209–244 (1879).

    Google Scholar 

  • Koch, F.: Niereninsuffizienz durch Oxalsäure-Vergiftung. Dtsch. Arch. klin. Med.169, 100–119 (1930).

    Google Scholar 

  • Koch, J., andE. L. R. Stokstad: Partial purification of a 2-oxo-glutarate: glyoxylate carboligase from rat liver mitochondria. Biochem. biophys. Res. Comm.23, 585–591 (1966).

    Article  PubMed  Google Scholar 

  • ——H. E. Williams, andL. H. Smith: Deficiency of 2-oxo-glutarate: glyoxylate carboligase activity in primary hyperoxaluria. Proc. nat. Acad. Sci. (Wash.)57, 1123–1129 (1967).

    Google Scholar 

  • Kohman, E. F.: Oxalic acid in foods and its behaviour and fate in the diet. J. Nutr.18, 233–246 (1939).

    Google Scholar 

  • Koten, J. W., C. van Gastel, E. J. Dorhout Mees, L. W. J. Holleman, andR. D. Schuiling: Two cases of primary oxalosis. J. clin. Path.18, 223–229 (1965).

    PubMed  Google Scholar 

  • Lehmann, E., u.W. Grutz: Zur Methodik der Oxalsäurebestimmung in Pflanzen. Pflanz. Ernähr. Dung.61, 77–86 (1953).

    Google Scholar 

  • Lommel, F.: Über die Herkunft der Oxalsäure im Harn. Dtsch. Arch. klin. Med.63, 599–611 (1899).

    Google Scholar 

  • Lovelage, F. E., C. H. Liu, andC. M. McCay: Age of animals in relation to the utilization of calcium and magnesium in the presence of oxalates. Arch. Biochem.27, 48–56 (1950).

    PubMed  Google Scholar 

  • Ludwig, G. D.: Renal calculi associated with hyperoxlauria. Ann. N.Y. Acad. Sci.104, 621–637 (1963).

    PubMed  Google Scholar 

  • Macaluso, M. P., andN. O. Berg: Calcium oxalate crystals in kidneys in acute tubular nephrosis and other renal diseases with functional failure. Acta path microbiol. scand.46, 197–205 (1959).

    PubMed  Google Scholar 

  • Martonosi, A., andR. Feretos: Sarcoplasmic reticulum. I. The uptake of Ca++ by sarcoplasmic reticulum fragments. J. biol. Chem.239, 648–658 (1964).

    PubMed  Google Scholar 

  • Mayer, G. G., D. Markow, andF. Karp: Enzymatic oxalate determination in urine. Clin. Chem.9, 334–339 (1963).

    PubMed  Google Scholar 

  • McLaurin, A. W., W. R. Beisel, G. J. McCormick, R. Scalettar, andR. H. Herman: Primary hyperoxaluria. Ann. intern. Med.55, 70–80 (1961).

    PubMed  Google Scholar 

  • Medes, G.: Solubility of calcium oxalate and uric acid in solutions of urea. Proc. Soc. exp. Biol. (N.Y.)30, 281–284 (1932).

    Google Scholar 

  • Metzler, D. E., J. Olivard andE. E. Snell: Transamination of pyridoxamine and amino acids with glyoxylic acid. J. Amer. chem. Soc.76, 644–648 (1954).

    Article  Google Scholar 

  • Miller, G. H., C. W. Vermeulen, andJ. D. Moore: Calcium oxalate solubility in urine: Experimental urolithiasis XIV. J. Urol. (Baltimore)79, 607–612 (1958).

    Google Scholar 

  • Morii, H., T. Fujita, andS. Okinaka: Effect of vagotomy and atropine on recovery from induced hypocalcemia. Endocrinology72, 173–179 (1963).

    Google Scholar 

  • Morris, M. P., andJ. Garcia-Rivera: The destruction of oxalates by the rumen contents of cows. J. Dairy Sci.38, 1169 (1955).

    Google Scholar 

  • Mugler, A.: Lithiase oxalique recidivante procedant d'une oxalose mineure chez l'adulte. Rein et Foie10, 261–268 (1967).

    Google Scholar 

  • Mukai, T., andJ. E. Howard: Some observations on the calacification of rachitic cartilage by urine. Bull. Johns Hopk. Hosp.112, 279–290 (1963).

    Google Scholar 

  • Nakada, H. I., andL. P. Sund: Glyoxylic acid oxidation by rat liver. J. biol. Chem.233, 8–13 (1958).

    PubMed  Google Scholar 

  • Neuman, W. F., andM. W. Neuman: The chemical dynamics of bone mineral. Chicago: Chicago University Press 1958.

    Google Scholar 

  • Nicholas, H. O.: Urinary calculi I. A simple semiquantitative method of analysis. Clin. Chem.4, 261–266 (1958).

    PubMed  Google Scholar 

  • Nordin, B. E. C., andA. Hodgkinson: Chapter in: Advances in internal medicine (ed.W. Dock andI. Snapper), p. 155. Chicago: Year Book Medical Publ. Inc. 1967.

    Google Scholar 

  • Nordin, B. E. C., andW. G. Robertson: Calcium phosphate and oxalate ion products in normal and stoneforming urines. Brit. med. J.1966 I, 450–453.

  • Novoa, W. B., andG. W. Schwert: Lactic dehydrogenase VIII. Binding of oxamate and of oxalate by enzyme-coenzyme complexes. J. biol. Chem.236, 2150–2153 (1961).

    PubMed  Google Scholar 

  • Pernet, J. L., andL. Pernet: Dosage colorimetrique de l'acide oxalique dans les milieux biologiques. Ann. Biol. clin.23, 1189–1207 (1965).

    Google Scholar 

  • Polson, C. J., andR. N. Tattersall: Clinical toxicology. London: English Universities Press 1959.

    Google Scholar 

  • Powers, H. H., andP. Levatin: A method for the determination of oxalic acid in urine. J. biol. Chem.154, 207–214 (1944).

    Google Scholar 

  • Prien, E. L., andC. Frondel: Studies in urolithiasis I. The composition of urinary calculi. J. Urol. (Baltimore)57, 949–991 (1947).

    Google Scholar 

  • —, andB. S. Walker: Salicyclamide and acetyl-saliylic acid in recurrent urolithiasis. J. Amer. med. Ass.160, 355–360 (1956).

    Google Scholar 

  • Pyrah, L. N., C. K. Anderson, A. Hodgkinson, andP. M. Zarembski: A case of oxalate nephrocalcinosis and primary hyperoxaluria. Brit. J. Urol.31, 235–248 (1959).

    PubMed  Google Scholar 

  • Raaflaub, J.: Komplexchemische Grundlagen der Harnsteingenese. Helv. med. Acta30, 724–755 (1963).

    Google Scholar 

  • Ratner, S., V. Nocito, andD. E. Green: Glycine oxidase. J. biol. Chem.152, 119–133 (1944).

    Google Scholar 

  • Ribeiro, M. E., andJ. S. Elliot: Direct enzymatic determination of urinary oxalate. Invest. Urol.2, 78–81 (1964).

    Google Scholar 

  • Roberts, A. H., andJ. Yudkin: Dietary phytate as a possible cause of magnesium deficiency. Nature (Lond.)185, 823–825 (1960).

    Google Scholar 

  • Robertson, W. G.: Personal communication 1968.

  • Salant, W., W. M. Parkins, andL. E. Sheppard: A study of blood calcium after the administration of sodium oxalate to normal and thyroparathyroidectomized cats. J. Lab. clin. Med.19, 142–152 (1933).

    Google Scholar 

  • Scowen, E. F., A. G. Stansfeld, andR. W. E. Watts: Oxalosis and primary hyperoxaluria. J. Path. Bact.77, 195–205 (1959).

    Article  PubMed  Google Scholar 

  • Seubert, W., andW. Huth: On the mechanism of gluconeogenesis and its regulation II. The mechanism of gluconeogenesis from pyruvate and fumarate. Biochem. Z.343, 176–191 (1965).

    PubMed  Google Scholar 

  • Shirley, E. K., andK. Schmidt-Nielsen: Oxalate metabolism in the pack rat, sand rat, hamster and white rat. J. Nutr.91, 496–502 (1967).

    PubMed  Google Scholar 

  • Sillen, L. G., andA. E. Martell: Stability constants of metal-ion complexes. London: The chemical Society 1964.

    Google Scholar 

  • Solomons, C. C., S. I. Goodman, andC. M. Riley: Calcium carbimide in the treatment of primary hyperoxaluria. New Engl. J. Med.276, 207–210 (1967).

    PubMed  Google Scholar 

  • Spencer, H., J. Greenberg, E. Berger, M. Perrone, andD. Lasilo: Studies on the effect of ethylenediamine-tetraacetic acid in hypercalcemia. J. Lab. clin. Med.47, 29–41 (1956).

    PubMed  Google Scholar 

  • Stewart, G. S., andH. F. Bowen: The parathyroid control of serum calcium independent of renal function. Endocrinology48, 568–575 (1951).

    PubMed  Google Scholar 

  • Stewart, P. R., andJ. R. Quayle: The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria. Biochem. J.102, 885–897 (1967).

    Google Scholar 

  • Tallqvist, H., andI. Vaananen: Death of a child from oxalic acid poisoning due to eatin rhubarb leaves. Ann. Paediat. Fenn.6, 144–147 (1960).

    PubMed  Google Scholar 

  • Weast, R. C., S. M. Selby, C. D. Hodgman: Handbook of chemistry and physics, 45th ed. Cleveland: The Chemical Rubber Co. 1964.

    Google Scholar 

  • Weinhouse, S., andB. Friedmann: Metabolism of labelled 2-carbon acids in the intact rat. J. biol. Chem.191, 707–717 (1951).

    PubMed  Google Scholar 

  • Widmark, E. M. P., andG. Ahldin: Oxallic acid content of vegetable foodstuffs. Biochem. Z.265, 241–244 (1933).

    Google Scholar 

  • Williams, H. E., M. Wilson, andL. H. Smith: Studies on primary hyperoxaluria. III. Transamination reactions of glyoxylate in human tissue preparations. J. Lab. clin. Med.70, 494–502 (1967).

    PubMed  Google Scholar 

  • Wyngaarden, J. B., andT. D. Elder: Chapter in: The metabolic basis of inherited disease (ed.J. B. Stanbury, J. B. Wyngaarden andD. S. Fredrickson), p. 189. New York: McGraw-Hill 1966.

    Google Scholar 

  • Zarembski, P. M., andA. Hodgkinson: The determination of oxalic acid in food. Analyst87, 698–702 (1962a).

    Article  Google Scholar 

  • ——: The oxalic acid content of English diets. Brit. J. Nutr.16, 627–634 (1962b).

    Article  PubMed  Google Scholar 

  • ——: The renal clearance of oxalic acid in normal subjects and in patients with primary hyperoxaluria. Invest. Urol.1, 87–93 (1963).

    Google Scholar 

  • ——: The fluorimetric determination of oxalic acid in blood and other biological materials. Biochem. J.96, 717–721 (1965).

    PubMed  Google Scholar 

  • ——: Plasma oxalic acid and calcium levels in oxalate poisoning. J. clin Path.20, 283–285 (1967).

    PubMed  Google Scholar 

  • ——, andF. M. Parsons: Elevation of the concentration of plasma oxalic acid in renal failure. Nature (Lond.)212, 511–512 (1966).

    Google Scholar 

  • Zimmerman, L. E., andF. B. Johnson: Calcium oxalate crystals within occular tissues. Arch. Ophthal.60, 372–383 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hodgkinson, A., Zarembski, P.M. Oxalic acid metabolism in man: A review. Calc. Tis Res. 2, 115–132 (1968). https://doi.org/10.1007/BF02279201

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02279201

Key words

Navigation