Abstract
Phenytoin, at a concentration which is known to inhibit parathyroid extract-induced bone resorptionin vitro, has been shown to have no significant effect on either the cyclic AMP content of four-day-old mouse calvaria which had been in tissue culture for 48 h or on the increase in cyclic AMP content occurring after the addition of parathyroid extract to the medium. Phenytoin has also been shown to be an effective inhibitor of bone resorptionin vitro induced by 25-hydroxycholecalciferol. These observations suggest that the inhibitory effect of phenytoin on parathyroid extract and hormone-induced bone resorption takes place beyond the cyclic AMP stage.
This is a preview of subscription content, log in via an institution to check access.
References
Ashby, J. P., Heaton, F. W.: The influence of magnesium deficiency and parathyroid hormone on adenosine 3′, 5′ cyclic monophosphate concentrations in rat kidney cortex. Biochem. Soc. Trans.1, 884–886 (1973)
Brown, B. L., Albano, J. D. M., Ekins, R. P., Sgherzi, A. M., Tampion, W.: A simple and sensitive saturation assay method for the measurement of adenosine 3′, 5′ cyclic monophosphate. Biochem. J.121, 561–562 (1971).
Care, A. D., Bates, R. F. L., Gitleman, H. J.: A possible role for the adenyl cyclase system in calcitonin release. J. Endocr.48, 1–15 (1970).
Chase, L. R., Aurbach, G. D.: The effect of parathyroid hormone on the concentration of adenosine 3′, 5′ monophosphate in skeletal tissuein vitro. J. biol. Chem.245, 1520–1526 (1970)
Fichman, M. P., Kleeman, C. R., Bethune, J. E.: Inhibition of anti-diuretic hormone secretion by diphenylhydantoin. Arch. Neurol. (Chic.)22, 45–53 (1970).
Harris, M., Jenkins, M. V., Wills, M. R.: Phenytoin inhibition of parathyroid hormone induced bone resorptionin vitro. Brit. J. Pharmacol.50, 405–409 (1974)
Herrath, D. von, Kraft, D., Schaefer, K., Koeppe, P.: Influence of pheno barbitone and diphenylhydantoin on vitamin D metabolism and calcium retention in rats. Z. ges. exp. Med.158, 194–204 (1972)
Herrmann-Erlee, M. P. M., Konijn, T. M.: Effect of parathyroid extract on cyclic AMP content of embryonic mouse calvaria. Nature (Lond.)227, 177–178 (1970)
Jenkins, M. V., Harris, M., Wills, M. R.: The effect of anticonvulsant drugsin vitro on bone calcium mobilisation by parathyroid hormone. Clin. Sci. Mol. Med.45, 1P-2P (1973)
Koch, H. V., Kraft, D., Herrath, D. von, Schaefer, K.: Influence of diphenylhydantoin and phenobarbital on intestinal calcium transport in the rat. Epilepsia (Amst.)13, 829–834 (1972)
Leading Article: Anticonvulsant Osteomalacia. Lancet1972 II, 805–806
Levin, S. R., Grodsky, G. M., Hagura, R., Smith, D.: comparison of the inhibitory effects of diphenylhydantoin and diazoxide upon insulin secretion from the isolated perfused pancreas. Diabetes21, 856–862 (1972)
Malherbe, C., Burrill, K. C., Levin, S. R., Karam, J. H., Forsham, P. H.: Effect of diphenylhydantoin on insulin secretion in man. New Engl. J. Med.286, 339–342 (1972)
Murad, F., Brewer, H. B., Vaughan, M.: Effect of thyrocalcitonin on adenosine 3′, 5′ cyclic phosphate formation by rat kidney and bone. Proc. nat. Acad. Sci. (Wash.)65, 446–453 (1970)
Nordentoft-Jensen, B., Grynderup, V.: Studies on the metabolism of phenytoin. Epilepsia (Amst.)7, 238–245 (1966)
Pento, J. T., Glick, S. M., Kagan, A.: Diphenylhydantoin inhibition of calcitonin secretion in the pig. Endocrinology92, 330–333 (1973)
Reynolds, J. J.: The effect of ascorbic acid on the growth of chick bone rudiments in chemically defined medium. Exp. Cell Res.42, 178–188 (1966)
Richens, A., Rowe, D. J. F.: Disturbance of calcium metabolism by anticonvulsant drugs. Brit. med. J.1970 IV, 73–76
Rinne, U. K.: Effect of diphenylhydantoin treatment on the release of corticotrophin in epileptic patients. Confin. neurol. (Basel)27 431–440 (1966)
Stamp, T. C. B., Round, J. M., Rowe, D. J. F., Haddad, J. G.: Plasma levels and therapeutic effect of 25-hydroxycholecalciferol in epileptic patients taking anticonvulsant drugs., Brit. med. J.1972 IV, 9–12
Sussman, K. E., Vaughan, G. D.: Insulin release after A.C.T.H., glucagon and adenosine 3′, 5′ phosphate (cyclic AMP) in the perfused isolated rat pancreas. Diabetes16, 449–454 (1967)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jenkins, M.V., Harris, M. & Wills, M.R. The effect of phenytoin on parathyroid extract and 25-hydroxycholecalciferol-induced bone resorption: Adenosine 3′, 5′ cyclic monophosphate production. Calc. Tis Res. 16, 163–167 (1974). https://doi.org/10.1007/BF02008223
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02008223