Summary
The analysis of a sample of 100 isoacentric (IA) and isocentric (IC) chromosomes, which had originated from spontaneous or radiation-induced deletions in human lymphocytes, is reported. IC and also IA have a strong tendency to be formed after breakage in juxtacentromeric heterochromatin. When euchromatic regions are involved, the breaks are not distributed at random since they frequently occur at places where juxtacentromeric heterochromatin exists in other primate species. It is assumed that intercalary structures conserving some of the properties of heterochromatin exists in human chromosomes in intercalary positions.
Similar content being viewed by others
References
Aurias A, Dutrillaux B (1986) A possible new type of chromosome rearrangement: telomere-centromere translocation (tct) followed by double duplication. Hjm Genet 72:25–26
Barbi G, Steinbach P, Vogel W (1984) Non random distribution of methotrexate induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites. Hum Genet 68:290–294
Dallapiccola B, Mastroiacovo P, Gandini E (1976) Centric fission of chromosome no. 4 in the mother of two patients with trisomy 4p. Hum Genet 31:121–125
Dubos C, Viegas-Pequignot E, Dutrillaux B (1978) Localization of Y-rays induced chromatid breaks using a three consecutive staining technique. Mutat Res 49:127–131
Dutrillaux B (1979) Chromosomal evolution in primates: tentative phylogeny from Microcebus murinus (prosimian) to man. Hum Genet 48:251–314
Dutrillaux B, Couturier J, Viegas-Pequignot E, Schaison G (1977) Localization of chromatid breaks in Fanconi's anemia, using three consecutive stains. Hum Genet 37:65–71
Dutrillaux B, Dubos C, Viegas-Pequignot E, Buriot D (1979) Partial endoreduplication: a new cytogenetic anomaly possibly related to a DNA repair defect. Ann Génét (Paris) 22:25–29
Dutrillaux B, Muleris M, Prieur M (1985) La localisation exacte de certains sites fragiles reste à préciser. Example du fra(10) sensible au folate. Ann Génét (Paris) 28:161–163
Dutrillaux B, Couturier J, Muleris M, Rumpler Y, Viegas-Pequignot E (1986) Relations chromosomiques entre sous-ordres et infraordres, et schéma évolutif général des Primates. Mammalia 50: 108–121
Fryns JP, Bulcke J, Hens L, Van Den Berghe H (1980) Balanced transmission of centromeric fission products in man. Hum Genet 54:127–128
Hansen S (1975) A case of centric fission in man: Humangenetik 26: 257–259
Human Gene Mapping 8 (1985) Eighth International Workshop on Human Gene Mapping 1985. Cytogenet Cell Genet 40
Janke D (1982) Centric fission of chromosome no. 7 in three generations. Hum Genet 60:200–201
Lejeune J, Dutrillaux B, Lafourcade J, Berger R, Abonyi D, Rethore MO (1968) Endoréduplication sélective du bras long du chromosome 2 chez une femme et sa fille. CR Acad Sci (Paris) 266:24–26
Marlhens F, Al Achkar W, Aurias A, Couturier J, Dutrillaux AM, Gerbault-Seureau M, Hoffschir F, Lamoliatte E, Lefrancois D, Lombard M, Muleris M, Prieur M, Prod'homme M, Sabatier L, Viegas-Pequignot E, Volobouev V, Dutrillaux B (1986) The rate of chromosome breakage is age dependent in lymphocytes of adult controls. Hum Genet 73:290–297
Muleris M, Couturier J, Dutrillaux B (1986) Phylogénie chromo-somique des Cercopithecoidea. Mammalia 50:38–55
Noel B, Quack B, Mottet J, Nantois Y, Dutrillaux B (1977) Selective endoreduplication or branched chromosome? Exp Cell Res 104: 423–426
Sinha AK, Pathak S, Nora JJ (1972) A human family suggesting evidence for centric fission and stability of a telocentric chromosome. Hum Hered 22:423–429
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dutrillaux, B., Achkar, W.A., Aledo, R. et al. Isoacentric and isocentric chromosomes originating after deletions of human chromosomes. Hum Genet 76, 244–247 (1987). https://doi.org/10.1007/BF00283616
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00283616