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Comparison of the half-life of antipyrine in plasma, whole blood and saliva of man

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Summary

A previously described GLC method has been modified and applied to measurement of antipyrine levels in plasma, blood and saliva of man following administration of a single oral dose (10 mg/kg). The levels in blood and saliva were comparable to those in plasma at every time studied. The half life of antipyrine determined in blood, plasma or saliva in any given individual was similar. The intersubject variation in half-life was about two-fold (n=5). Antipyrine levels in saliva were not affected by the rate of saliva flow when collections were made continuously for 20 minutes. This study has demonstrated that kinetic data about antipyrine comparable to that from plasma may also be obtained from readily accessible tissue fluids, such as saliva and capillary blood.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden

    C. J. van Boxtel, J. T. Wilson, S. Lindgren & F. Sjöqvist

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  1. C. J. van Boxtel
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  2. J. T. Wilson
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  3. S. Lindgren
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  4. F. Sjöqvist
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van Boxtel, C.J., Wilson, J.T., Lindgren, S. et al. Comparison of the half-life of antipyrine in plasma, whole blood and saliva of man. Eur J Clin Pharmacol 9, 327–332 (1976). https://doi.org/10.1007/BF00561668

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  • DOI: https://doi.org/10.1007/BF00561668

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