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Ketoprofen and indomethacin in the treatment of rheumatoid arthritis: A double-blind cross-over trial

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Summary

In a double-blind cross-over trial in 36 patients with rheumatoid arthritis, ketoprofen 150 mg and indomethacin 100 mg daily had similar therapeutic effects. Side-effects of the two drugs were comparable and were trivial.

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References

  1. Cathcart, B.J., Vince, J.D., Gordon, A.J., Bell, M.A., Chalmers, I.M.: Studies on 2-(3-benzoyl-phenyl) propionic acid (Orudis). A double-blind cross-over trial in patients with rheumatoid arthritis and an assessment of its influence on hepatic drug-metabolizing enzymes. Ann. Rheum. Dis.32 62 (1972)

    Google Scholar 

  2. Grizzle, J.E.: The two period change-over design and its use in clinical trials. Biometrics21 467 (1965)

    Google Scholar 

  3. Gyory, A.M., Bloch, M., Burry, H.C., Grahame, R.: Orudis in management of rheumatoid arthritis and osteoarthritis of the hip: comparison with indomethacin. Brit. med. J.1972 IV 398

    Google Scholar 

  4. Julou, L., Guyonnet, J.C., Ducrot, R., Garret, C., Bardone, M.C., Maignan, G., Pasquet, J.: Etudes des proprietés pharmacologiques d'un nouvel anti-inflammatoire, l'acide (benzoyl-3-phenyl)-2-propionique (19583 R.P.). J. Pharmacol. (Paris)2 259 (1971)

    Google Scholar 

  5. Krupp, M.A., Chatton, M.J.: Current diagosis and treatment. Los Altos: Lange Med. Pub. 1973

    Google Scholar 

  6. Li, J.C.R.: Statistical Inference I. Ann Arbor: Edwards Brothers 1964

    Google Scholar 

  7. Ropes, M.W., Bewnet, C.A., Cobb, S., Jacox, R., Jessar, R.A.: Diagnostic criteria for rheumatoid arthritis. Ann. Rheum. Dis.18 49 (1959)

    Google Scholar 

  8. Steinbrocker, O., Traeger, C.H., Batterman, R. C.: Therapeutic criteria in rheumatoid arthritis. J. Amer. med. Ass.140 659 (1949)

    Google Scholar 

  9. Thompson, M., Percy, J.S.: Further experience with indomethacin in the treatment of rheumatic disorders. Brit. med. J.1966 I 80

    Google Scholar 

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Authors and Affiliations

  1. Rheumatology Dept. S. Corona Hospital, Pietra Ligure, Italy

    M. Viara, R. Franchi, C. Liverta, C. Pollini & A. E. Pontiroli

  2. Orthopaedic Dept., Cantù General Hospital and Medical Research Division, Farmitalia, Milan, Italy

    M. Viara, R. Franchi, C. Liverta, C. Pollini & A. E. Pontiroli

Authors
  1. M. Viara
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  2. R. Franchi
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  3. C. Liverta
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  4. C. Pollini
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  5. A. E. Pontiroli
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Viara, M., Franchi, R., Liverta, C. et al. Ketoprofen and indomethacin in the treatment of rheumatoid arthritis: A double-blind cross-over trial. Eur J Clin Pharmacol 8, 205–208 (1975). https://doi.org/10.1007/BF00567116

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  • DOI: https://doi.org/10.1007/BF00567116

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