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The cardiovascular effects of etilefrine

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Summary

Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Peripheral vascular resistance falls during the infusion of 1 – 8 mg etilefrine but begins to rise at higher dosage. Marked falls in pulse rate, cardiac output, stroke volume and peripheral bloodflow, accompanied by rises in mean arterial pressure, occur when etilefrine is infused after administration of intravenous propranolol 2,5 mg. These findings indicate that etilefrine has both β1 and α adrenergic effects in man.

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Authors and Affiliations

  1. Northwick Park Hospital, London, England

    A. J. Coleman, W. P. Leary & A. C. Asmal

  2. Dept. of Clinical and Experimental Pharmacology, Faculty of Medicine, University of Natal, Durban, Republic of South Africa

    A. J. Coleman, W. P. Leary & A. C. Asmal

Authors
  1. A. J. Coleman
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  2. W. P. Leary
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  3. A. C. Asmal
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Coleman, A.J., Leary, W.P. & Asmal, A.C. The cardiovascular effects of etilefrine. Eur J Clin Pharmacol 8, 41–45 (1975). https://doi.org/10.1007/BF00616413

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  • DOI: https://doi.org/10.1007/BF00616413

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