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Twelve hour (trough) plasma nifedipine concentrations during chronic treatment with nifedipine retard

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Summary

Variations in plasma nifedipine concentrations have been reported and one study has suggested the existence of a subpopulation of poor metabolisers of this drug. We have studied the variability of 12 h plasma nifedipine concentrations in 64 hypertensive patients on long-term nifedipine Retard 20 mg twice daily. A slightly skewed unimodal distribution with a modal concentration of 15 to 30 ng/ml was obtained. No relationship between 12-h plasma levels and debrisoquine hydroxylation phenotype was found.

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Authors and Affiliations

  1. Department of Therapeutics, Queen Elizabeth Hospital, Edgbaston, Birmingham 15, U.K.

    M. Beerahee, M. R. Wilkins, D. B. Jack & M. J. Kendall

  2. Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham 15, U.K.

    D. G. Beevers

Authors
  1. M. Beerahee
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  2. M. R. Wilkins
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  3. D. B. Jack
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  4. D. G. Beevers
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  5. M. J. Kendall
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Beerahee, M., Wilkins, M.R., Jack, D.B. et al. Twelve hour (trough) plasma nifedipine concentrations during chronic treatment with nifedipine retard. Eur J Clin Pharmacol 32, 347–349 (1987). https://doi.org/10.1007/BF00543967

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  • DOI: https://doi.org/10.1007/BF00543967

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