Summary
The plasma concentration curves and urinary excretion of oxmetidine after administration of single i.v. (100 mg) and oral (200 mg) doses have been studied in 11 patients with peptic ulcer disease. The mean bioavailability of the drug was 70% (range 53–91%). After intravenous administration, the mean plasmat 1/2β was 3.0 h, the mean apparent volume of distribution 0.7 l/kg, the mean total plasma clearance 12.3 l/h and the mean plasma renal clearance was 0.7 l/h. Following intravenous and oral administration an average of 6% and 3%, respectively, of unchanged drug was found in the urine. The plasma concentration curve after oral administration in most patients exhibited two maxima, with peak concentrations appearing between 45 and 210 min after dosing.
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Bodemar G, Norlander B, Fransson L, Walan A (1979) The absorption of cimetidine before and during maintenance treatment with cimetidine and the influence of a meal on absorption of cimetidine-studies in patients with peptic ulcer disease. Br J Clin Pharmacol 7: 23–31
Bodemar G, Norlander B, Walan A (1981) Pharmacokinetics of cimetidine after single doses and during continous treatment. Clin Pharmacokinet 6: 306–315
Gugler R, Somogyi A, Bergman Kv (1981) The biliary excretion of histamine H2-receptor antagonists cimetidine and oxmetidine. Clin Pharmacol Ther 29: 249–250
Mills JG, Brunet PL, Griffiths R, Hunt RH, Vincent D, Milton-Thompson GJ, Burland WL (1982) Oxmetidine-clinical pharmacological studies with a new H2-receptor antagonist. Gut 23: 157–163
Porro BG, Petrillo M, Lazzaroni M, Leto di Priolo S (1981) Healing of duodenal ulcer with twice daily oxmetidine, Part 2. In: Baron JH (ed) Cimetidine in the 80's. Churchill Livingstone, Edinburgh London Melbourne New York
Rohner HG, Brandstätter G, Kratochvil P, Kollmeier J, Gugler R (1981) Healing of duodenal ulcer with twice daily oxmetidine, Part 1. In: Baron JH (ed) Cimetidine in the 80's. Churchill Livingstone, Edinburgh London Melbourne New York
Sharpe PC, Melvin MA, Mills JG, Burland WL, Groom CV (1980) Prolactin responses to histamin H2-receptor antagonists. Acta Endocrinol 95: 308–313
Somogyi A, Gugler R (1980) Gastric acid inhibitors effect and pharmacokinetics of a new histamine H2 antagonist, 92994. Hepatogastroenterology. Abstracts: XI Internat Congr of Gastroenterology E 32.13, p 260
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Jönsson, K.Å., Bodemar, G., Gotthard, R. et al. Pharmacokinetics of oxmetidine, a new histamine H2-receptor antagonist, after single oral and intravenous doses. Eur J Clin Pharmacol 24, 353–356 (1983). https://doi.org/10.1007/BF00610054
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DOI: https://doi.org/10.1007/BF00610054