Skip to main content
SpringerLink
Log in

Study of the Influence of Several Stabilizing Agents on the Entrapment and In Vitro Release of pBC 264 from Poly(Lactide-Co-Glycolide) Microspheres Prepared by a W/O/W Solvent Evaporation Method

  • Note
  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

REFERENCES

  1. P. Couvreur and F. Puisieux. Nano-and microparticles for the delivery of polypeptides and proteins. Adv. Drug Deliv. Rev. 10:141–162 (1993).

    Google Scholar 

  2. D. T. O'Hagan, D. Rahman, J. P. McGee, H. Jeffery, M. C. Davies, P. Williams, S. S. Davies, and S. J. Challacombe. Biodegradable microparticles as controlled release antigen delivery systems. Immunology 73:239–242 (1991).

    Google Scholar 

  3. M. J. Blanco-Prieto, F. Delie, E. Fattal, A. Tartar, F. Puisieux, A. Gulik, and P. Couvreur. Characterization of V3 BRU peptide-loaded small PLGA microspheres prepared by a (W1/O)W2 emulsion solvent evaporation method. Int. J. Pharm. 111:137–145 (1994).

    Google Scholar 

  4. H. Toshiro, H. Okada, Y. Tanigawara, Y. Ogawa, and H. Toguchi. Effects of counteranion of TRH and loading amount on control of TRH release from copoly(dl-lactic/glycolic acid) microspheres prepared by an in-water drying method. Int. J. Pharm. 69:69–75 (1991).

    Google Scholar 

  5. B. Charpentier, C. Durieux, D. Peleprat, A. Dor, M. Reibaud, J. C. Blanchard, and B. P. Roques. Enzyme-resistant CCK analogs with high affinities for central receptors. Peptides 9:835–841 (1988).

    Google Scholar 

  6. M. J. Blanco-Prieto, E. Fattal, F. Delie, A. Gulik, B. P. Roques, and P. Couvreur. Characterization and morpholigical analysis of a cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microspheres prepared by a water-in-oil-in-water method. J. Contr. Rel., in press.

  7. M. S. Hora, R. K. Rana, J. H. Nummberg, T. R. Tice, R. M. Gilley, and M. E. Hudson. Release of human serum albumin from poly(lactide-co-glycolide) microparticles. Pharm. Res. 7:1190–1194 (1990).

    Google Scholar 

  8. C. Schugens, N. Laurelle, N. Nihant, Ch. Grandfils, R. Jérome, P. Teyssie. Effect of the emulsion stability on the morphology and porosity of semycristalline poly 1-lactide microparticles prepared by W/O/W double emulsion evaporation. J. Contr. Rel. 32:161–176 (1994).

    Google Scholar 

  9. N. Nihant, C. Schugens, Ch. Grandfils, R. Jerome, and P. Teyssie. Polylactide microparticles prepared by double emulsion/evaporation technique. 1. Effect of primary emulsion stability. Pharm. Res. 11:1479–1484 (1994).

    Google Scholar 

  10. N. Garti, A. Aserin, and Y. Cohen. Mechanistic considerations on the release of electrolytes from multiple emulsions stabilized by BSA and nonionic surfactants. J. Contr. Rel. 29:41–51 (1994).

    Google Scholar 

  11. T. Sato, M. Kanke, H. G. Schoroeder, and P. Deluca. Porous biodegradable microspheres for controlled drug delivery. I. Assesment of processing conditions and solvent removal techniques. Pharm. Res. 5:21–30 (1988).

    Google Scholar 

  12. H. Sah, R. Toddywala, and Y. W. Chien. The influence of biodegradable microcapsule formulation on the controlled release of a protein. J. Contr. Rel. 30:201–211 (1994).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire Physico-Chimie—Pharmacotechnie—Biopharmacie, URA CNRS 1218, Faculté de Pharmacie, 5, Rue Jean Baptiste Clément, 92296, Chatenay Malabry, Cedex, France

    María J. Blanco-Príeto, Eliana Leo, Patrick Couvreur & Elias Fattal

  2. Genentech Incorporated, 460 Point San Bruno Blvd, South San Francisco, California, 94080

    Florence Delie

  3. Centre de Génétique Moléculaire, UPR A2420, 91198, Gif-sur-Yvette, Cedex, France

    Annette Gulik

Authors
  1. María J. Blanco-Príeto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eliana Leo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Florence Delie
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Annette Gulik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Patrick Couvreur
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Elias Fattal
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blanco-Príeto, M.J., Leo, E., Delie, F. et al. Study of the Influence of Several Stabilizing Agents on the Entrapment and In Vitro Release of pBC 264 from Poly(Lactide-Co-Glycolide) Microspheres Prepared by a W/O/W Solvent Evaporation Method. Pharm Res 13, 1127–1129 (1996). https://doi.org/10.1023/A:1016087530812

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016087530812

Search

Navigation