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Effect on different mutant p53 on cell sensitivity to cytostatics

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Expression of human p53 carrying missense mutations at codons 175 (His175), 194 (His194), 248 (Trp248), and 273 (His273) has different effects on sensitivity of K562, 10(1), 10(3), and Rat1 cells to the antitumor drugs methotrexate, etoposide, vinblastine. These effects of mutant p53 depend on both particular amino acid substitution and cell context (histogenetic type, status of the second allele,etc.)

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Authors and Affiliations

  1. Laboratory of Cytogenetics, N. N. Blokhin Oncology Research Center, Russian Academy of Medical Sciences, Moscow

    O. Yu. Semenyak & B. P. Kopnin

  2. Laboratory of Cell Proliferation, Institute of Molecular Biology, Russian Academy of Sciences, Moscow

    P. M. Chumakov

Authors
  1. O. Yu. Semenyak
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  2. P. M. Chumakov
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  3. B. P. Kopnin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 324–327, March, 1999

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Semenyak, O.Y., Chumakov, P.M. & Kopnin, B.P. Effect on different mutant p53 on cell sensitivity to cytostatics. Bull Exp Biol Med 127, 293–295 (1999). https://doi.org/10.1007/BF02433361

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  • DOI: https://doi.org/10.1007/BF02433361

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