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Phospholipase A2 inhibitors from marine algae

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Abstract

Twelve out of twenty-nine compounds isolated from benthic marine algae from the phyla Chlorophyta, Phaeophyta and Rhodophyta have been found to be potent inhibitors of bee venom derived phospholipase A2 (PLA2) (> 50%) in the μM range. The compounds investigated were from: Bryopsis pennata, Rhipocephalus phoenix, Caulerpa prolifera, C. racemosa, C. bikinensis, Cymopolia barbata, Laurencia cf. palisada, Laurencia sp., Ochtodes crockeri, Liagora farinosa, Sphaerococcus coronipifolius, Phacelocarpus labillardieri, Dictyota sp., B furcaria galapagensis, Stypopodium zonale, Dictyopteris undulata, Stoechospermum marginatum, Dictyopteris divaricata, Dilophus fasciola and Dilophus sp. This is the first report of bee venom PLA2 inhibition in vitro by pure compounds isolated from marine algae.

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Authors and Affiliations

  1. Louisiana State University Medical Center, Department of Physiology, 1901 Perdido Street, 70112-1393, New Orleans, LA, USA

    Alejandro M. S. Mayer

  2. University of Guam - Marine Laboratory, UOG Station, 96923, Mangilao, Guam, USA

    Valerie J. Paul

  3. Scripps Institution of Oceanography, University of California - San Diego, 92093-0236, La Jolla, CA, USA

    William Fenical

  4. Department of Botany, NH B166, National Museum of Natural History, Smithsonian Institution, 20560, Washington, D. C., USA

    James N. Norris

  5. Department of Biological Sciences, University of California-Santa Barbara, 93106, Santa Barbara, CA, USA

    M. S. de Carvalho & Robert S. Jacobs

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  1. Alejandro M. S. Mayer
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  2. Valerie J. Paul
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  3. William Fenical
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Mayer, A.M.S., Paul, V.J., Fenical, W. et al. Phospholipase A2 inhibitors from marine algae. Hydrobiologia 260, 521–529 (1993). https://doi.org/10.1007/BF00049065

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