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Alterations in the fraction of oxygen in inspired gas affect rates of renal prostaglandin E2 synthesis in anesthetized dogs

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Summary

Reductions of oxygen in inspired gas from 20% to 15%, in anesthetized dogs, reduced arterial PO2 and increased the renal efflux of PGE2 but not PGF2a . Renal blood flow, blood pressure, plasma renin activity as well as arterial pH and PCO2 were unaffected. PGs may mediate the renal hemodynamic or excretory consequences of alterations in PO2. In addition, minor variations in PO2 might account, in part, for the variable renal venous PGE2 concentrations reported under basal conditions.

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Authors and Affiliations

  1. Departments of Medicine, Veterans Administration Medical Center (111D JC), and St. Louis University School of Medicine, 63125, St. Louis, Missouri, USA

    A. J. Lonigro, A. H. Stephenson, L. J. Heitmann, D. W. Brash & R. S. Sprague

Authors
  1. A. J. Lonigro
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  2. A. H. Stephenson
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  3. L. J. Heitmann
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  4. D. W. Brash
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  5. R. S. Sprague
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Additional information

Authentic prostaglandins were supplied by Dr John E. Pike of the Upjohn Company. This work was supported by grants from the Veterans Administration, the Southern Medical Association and U.S. Public Health Service. Dr. Brash is an American Heart Association, Missouri Affiliate Fellow.

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Lonigro, A.J., Stephenson, A.H., Heitmann, L.J. et al. Alterations in the fraction of oxygen in inspired gas affect rates of renal prostaglandin E2 synthesis in anesthetized dogs. Experientia 37, 1293–1294 (1981). https://doi.org/10.1007/BF01948368

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