Skip to main content
SpringerLink
Log in

Selective activation of noradrenergic neurons in the brainstem and spinal cord of young spontaneously hypertensive rats

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

In young spontaneously hypertensive rats (SHR), dopamine β-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) activities were examined in the brainstem nuclei. Activation of noradrenergic neurons in the locus coeruleus, A2 and spinal intermediolateral cell areas, resulting in enhanced sympathetic nervous activity in the periphery, initiates hypertension. Adrenergic neurons, unchanged in these and A1 cell areas of young SHR, are not involved in the development of hypertension in SHR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. Thoenen, Life Sci.14, 223 (1974).

    Article  CAS  PubMed  Google Scholar 

  2. I.B. Black, E.M. Bloom and R.W. Hamil, Proc. nat. Acad. Sci. USA73, 3575 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. H. Grobecker, M.F. Roizen, V. Weise, J.M. Saavedra and J.J. Kopin, Nature258, 267 (1975).

    Article  CAS  PubMed  Google Scholar 

  4. T. Nagatsu, K. Ikuta, Y. Numata, T. Kato, M. Sano, I. Nagatsu and T. Takeuchi, Science191, 290 (1976).

    Article  CAS  PubMed  Google Scholar 

  5. K. Nakamura and K. Nakamura, Nature266, 265 (1977).

    Article  CAS  PubMed  Google Scholar 

  6. K. Nakamura and K. Nakamura, Naunyn-Schmiedebergs Arch. Pharmak.299, 143 (1977).

    Article  CAS  Google Scholar 

  7. L.W. Swanson and B.K. Hartman, J. comp. Neurol.163, 467 (1975).

    Article  CAS  PubMed  Google Scholar 

  8. T. Hökfelt, K. Fuxe, M. Goldstein and O. Johansson, Brain Res.66, 235 (1974).

    Article  Google Scholar 

  9. T. Chiba and N. Doba, Brain Res.102, 255 (1976).

    Article  CAS  PubMed  Google Scholar 

  10. H.R. Kirchheim, Physiol. Rev.56, 100 (1976).

    Article  CAS  PubMed  Google Scholar 

  11. W. Zeman and J.R.M. Innes; in: Craigie's Neuroanatomy of the Rat. Academic Press, New York 1963.

    Google Scholar 

  12. J.L. Henry and F.R. Calaresu, Am. J. Physiol.222, 700 (1972).

    Article  CAS  PubMed  Google Scholar 

  13. M. Palkovits, Brain Res.59, 449 (1973).

    Article  CAS  PubMed  Google Scholar 

  14. J.M. Saavedra, M. Brownstein, M. Palkovits, S. Kizer and J. Axelrod, J. Neurochem.23, 869 (1974).

    Article  CAS  PubMed  Google Scholar 

  15. K.E. Moore and O.T. Phillipson, J. Neurochem.25, 289 (1975).

    Article  CAS  PubMed  Google Scholar 

  16. D.H. Lowry, N.J. Rosebrough, A.L. Farr and R.J. Randall, J. biol. Chem.193, 265 (1951).

    Article  CAS  PubMed  Google Scholar 

  17. R.D. Ciaranello and J. Axelrod, J. biol. Chem.248, 5616 (1973).

    Article  CAS  PubMed  Google Scholar 

  18. D.G. Ward and C.G. Gunn, Brain Res.107, 401 (1976).

    Article  CAS  PubMed  Google Scholar 

  19. H. Przuntek and G. Philippu, Naunyn-Schmiedebergs Arch. Pharmak.276, 119 (1973).

    Article  CAS  Google Scholar 

  20. D.H. Versteeg, M. Palkovits, J. Van der Gugten, H.L.J.M. Wijnen, G.W.M. Smeets and W. de Jong, Brain Res.112, 429 (1976).

    Article  CAS  PubMed  Google Scholar 

  21. A. Nagaoka and W. Lovenberg, Eur. J. Pharmac.43, 297 (1977).

    Article  CAS  Google Scholar 

  22. A. Dahlström and K. Fuxe, Acta physiol. scand.62, suppl. 232, 1 (1964).

    Google Scholar 

  23. L.-G. Nygren and L. Olson, Brain Res.132, 85 (1977).

    Article  CAS  PubMed  Google Scholar 

  24. J.A. Zivin, J.L. Reid, M.L. Tappaz and I.J. Kopin, Brain Res.105, 151 (1976).

    Article  CAS  PubMed  Google Scholar 

  25. J.A. Zivin, J.L. Reid, J.M. Saavedra and I.J. Kopin, Brain Res.99, 293 (1975).

    Article  CAS  PubMed  Google Scholar 

  26. J.M. Chung, K. Chung and R.D. Wurster, Brain Res.91, 126 (1975).

    Article  CAS  PubMed  Google Scholar 

  27. H.J.L.M. Wijnen, D.H.G. Versteeg, M. Palkovits and W. de Jong, Brain Res.135, 180 (1977).

    Article  CAS  PubMed  Google Scholar 

  28. S.H. Koslow and M. Schlumpf Nature251, 530 (1974).

    Article  CAS  PubMed  Google Scholar 

  29. J.M. Saavedra, H. Grobecker and J. Axelrod, Science191, 483 (1975).

    Article  Google Scholar 

  30. V. DeQuatro and Y. Miura, Am. J. Med.55, 363 (1973).

    Article  Google Scholar 

  31. S. Julius and M. Esler, Am. J. Cardiol.36, 685 (1973).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Nippon Roche Research Center, 247, Kamakura, Japan

    K. Nakamura & K. Nakamura

Authors
  1. K. Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakamura, K., Nakamura, K. Selective activation of noradrenergic neurons in the brainstem and spinal cord of young spontaneously hypertensive rats. Experientia 34, 1042–1043 (1978). https://doi.org/10.1007/BF01915335

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01915335

Keywords

Search

Navigation