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Inhibition of angiotensin-converting enzyme by analogs of peptides fromBothrops jararaca venom

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Zusammenfassung

Nachweis mit Analogen der im Gifte vonBothrops jararaca gefundenen Peptide, dass die Inhihibition des Angiotensins «converting enzyme» von zwei eindeutigen Teilsequenzen dieser Peptide abhängig ist. Die hohe spezifische kompetitive Inhibition, hervorgerufen durch die Peptide vonBothrops jararaca, wird der Bindung ihrer Tripeptidreste vom Carboxyterminus mit dem aktiven Zentrum des Enzyms zugeschrieben, die in gleicher Weise wie die Peptidsubstrate mit dem Enzym gebunden werden. Die Wirksamkeit der Giftpeptide hängt von der Bindung eines zweiten Teiles der Peptide mit dem Enzym ab.

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Authors and Affiliations

  1. The Squibb Institute for Medical Research, 08540, Princeton, New Jersey, USA

    D. W. Cushman, J. Pluščec, N. J. Williams, E. R. Weaver, E. F. Sabo, O. Kocy, H. S. Cheung & M. A. Ondetti

Authors
  1. D. W. Cushman
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  2. J. Pluščec
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  3. N. J. Williams
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  4. E. R. Weaver
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  5. E. F. Sabo
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  6. O. Kocy
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  7. H. S. Cheung
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  8. M. A. Ondetti
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Cushman, D.W., Pluščec, J., Williams, N.J. et al. Inhibition of angiotensin-converting enzyme by analogs of peptides fromBothrops jararaca venom. Experientia 29, 1032–1035 (1973). https://doi.org/10.1007/BF01930447

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