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The role of hypercapnia in acetazolamide teratogenesis

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  • Pharmacologica
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Zusammenfassung

Für die teratogene Wirkung von Acetazolamid beim Hamster ist nicht nur der die CO2-Konzentration erhöhende Effekt verantwortlich. Das Aussetzen der mit Acetazolamid behandelten Muttertiere in eine mit 10% CO2 angereicherte Atmosphäre erhöhte zwar die Inzidenz, nicht aber den Schweregrad der Missbildungen der Vorderextremität.

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Author information

Authors and Affiliations

  1. Department of Pathology, Dartmouth Medical School, 03755, Hanover, New Hampshire, USA

    Th. G. Storch & W. M. Layton Jr.

Authors
  1. Th. G. Storch
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  2. W. M. Layton Jr.
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Additional information

This work was supported by NIH grants No. HD 03298 and GM 00687, and the elective program of the Johns Hopkins University School of Medicine, Baltimore, Maryland. Acetazolamide was kindly supplied by Lederle Laboratories, Pearl River, N. Y.

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Storch, T.G., Layton, W.M. The role of hypercapnia in acetazolamide teratogenesis. Experientia 27, 534–535 (1971). https://doi.org/10.1007/BF02147583

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