Skip to main content
SpringerLink
Log in

A new type of non-kaliuretic diuretic compound

  • Specialia
  • Chimica. Biochimica
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Die Synthese von 1-(Pyrrolidino)-3,5-diphenyl-4-(α-pyridyl)-cyclohexan, Su-15049, und dessen wasserlöslichen Citrats werden beschrieben. Diese Verbindungen besitzen starke diuretische und natriuretische Eigenschaften; sie sind aber nicht kaliuretisch wirksam.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. M. M. Robison, W. G. Pierson, L. Dorfman, B. F. Lambert andR. A. Lucas, J. org. Chem.31, 3206 (1966).

    Article  CAS  Google Scholar 

  2. M. M. Robison, B. F. Lambert, L. Dorfman andW. G. Pierson, J. org. Chem.31, 3220 (1966).

    Article  CAS  Google Scholar 

  3. M. M. Robison, W. G. Pierson, L. Dorfman andB. F. Lambert, J. org. Chem.31, 3213 (1966).

    Article  CAS  Google Scholar 

  4. Dr.E. J. Cafruny, University of Minnesota (personal communication) has found that in dogs Su-15049A does not appreciably affect the glomerular filtration rate or paraminohippurate clearance. Stop-flow studies indicated that its marked enhancement of Na+ and Cl− excretion was exerted primarily in the proximal portion of the renal tubules. It may, however, affect distal ion exchange mechanisms in such a way as to result in the observed net lack of enhanced K+ excretion.

Download references

Author information

Authors and Affiliations

  1. Research Department, CIBA Pharmaceutical Company, 07901, Summit, New Jersey, USA

    M. M. Robison, A. A. Renzi & W. E. Barrett

Authors
  1. M. M. Robison
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Renzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. E. Barrett
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Robison, M.M., Renzi, A.A. & Barrett, W.E. A new type of non-kaliuretic diuretic compound. Experientia 23, 513–514 (1967). https://doi.org/10.1007/BF02137937

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02137937

Keywords

Search

Navigation