Sur certaines conditions de la transformation du type antigénique et de l'équipement enzymatique d'un colibacille, sous l'effet d'un principe inducteur de nature thymonucléique issu d'un autre colibacille (mutation « dirigée »)

Summary

The transformation of antigenic and enzymatic properties of a bacteria can be produced by the action of an inductor thymonucleic factor, which comes from a related bacteria. However, this transformation is only possible when the bacteria which must undergo the “mutation dirigée” is in a state of pronounced instability, the determinism of which is still unknown. We find to-day the greatest difficulties to isolate, without destroying it, the inductor factor, because it is very sensitive to bacterial enzyms and to the delayed action of acids and bases.