Abstract
Pattern formation in animal development requires that genes be expressed differentially according to position in the sheets of cells that make up the early embryo. The homoeobox-containing genes of Drosophila are control genes active both in the establishment of a segmentation pattern1,2 and in the specification of segment identity2,3. In situ hybridization experiments4–6 confirm that these genes are expressed in a segmentally-restricted manner and that their expression presages morphological differentation of segmental structures. Homoeobox genes have recently been isolated from the mouse7–12 and have been shown to be expressed during mouse development9–13. Using in situ hybridization, we show here that expression of the mouse homoeobox gene Mo-10 (ref. 7) is spatially restricted in the developing embryo and that localization of expression is already evident within the germ layers before their morphological differentiation. These findings support the suggestion14 that the homoeobox genes of mammals, like those of Drosophila, may be important in pattern formation.
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References
Kuroiwa, A., Hafen, E. & Gehring, W. J. Cell 37, 825–831 (1984).
Wakimoto, B. T. & Kaufman, T. C. Devl boil. 81, 51–64 (1981).
Lewis, E. B. Nature 276, 565–570 (1978).
Hafen, E., Kuroiwa, A. & Gehring, W. J. Cell 37, 833–841 (1984).
Levine, M., Hafen, E., Garber, R. L. & Gehring, W. J. EMBO J. 2, 2037–2046 (1983).
Akam, M. E. & Martinez-Arias, A. EMBO J. 4, 1689–1700 (1985).
McGinnis, W., Hart, C. P., Gehring, W. J. & Ruddle, F. H. Cell 38, 675–680 (1984).
Colberg-Poley, A. M., Voss, S. D., Chowdhury, K. & Gruss, P. Nature 314, 713–718 (1985).
Hart, C. P., Awgulewitsch, A., Fainsod, A., McGinnis, W. & Ruddle, F. H. Cell 43, 9–18 (1985).
Hauser, C. A. et al. Cell 43, 19–28 (1985).
Jackson, I. J., Schofield, P. & Hogan, B. Nature 317, 745–748 (1985).
Awgulewitsch, A., Utset, M. F., Hart, C. P., McGinnis, W. & Ruddle, F. H. Nature 320, 328–335 (1986).
Colberg-Poley, A. M. et al. Cell 43, 39–45 (1985).
McGinnis, W., Garber, R. L., Wirz, J., Kuroiwa, A. & Gehring, W. J. Cell 37, 403–408 (1984).
Melton, D. A. et al. Nucleic Acids Res. 12, 7035–7056 (1984).
Duboule, D., Baron, A., Mahl, P. & Galliot, B. EMBO J. 5, 1973–1980 (1986).
Cox, K. H., DeLeon, D. V., Angerer, L. M. & Angerer, R. C. Devl. Biol. 101, 485–502 (1984).
Ingham, P. W., Howard, K. R. & Ish-Horowicz, D. Nature 318, 439–445 (1985).
Derman, E. et al. Cell 23, 731–739 (1981).
Harding, K., Weeden, C., McGinnis, W. & Levine, M. Science 229, 1236–1242 (1985).
McConaughy, B. L., Laird, C. D. & McCarthy, B. J. Biochemistry 8, 3289–3295 (1969).
Lawrence, P. A. & Morata, G. Cell 35, 595–601 (1983).
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Gaunt, S., Miller, J., Powell, D. et al. Homoeobox gene expression in mouse embryos varies with position by the primitive streak stage. Nature 324, 662–664 (1986). https://doi.org/10.1038/324662a0
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DOI: https://doi.org/10.1038/324662a0
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