Abstract
ENDOTOXINS from Gram-negative bacteria, when added to human plasma or certain fractions of human plasma and incubated at 37° C for several hours, show reduced immunological reactivity, pyrogenicity, and toxicity1. Physical changes occur in such altered endotoxins, as manifested by a more rapid diffusion rate2,3 and a lowered ability to be sedimented in a high-speed centrifuge2,4 when compared with native endotoxin. The kinetics of the inactivation of endotoxin by plasma or its fractions suggested that the endotoxin was being degraded by a plasma enzyme. However, germane to the proof of such a tenet should be the isolation and identification of products which have come from a previously undergraded endotoxin. Examination of the literature revealed a paucity of such data.
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RUDBACH, J., JOHNSON, A. Restoration of Endotoxin Activity following Alteration by Plasma. Nature 202, 811–812 (1964). https://doi.org/10.1038/202811a0
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DOI: https://doi.org/10.1038/202811a0
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