Abstract
RECENTLY evidence has accumulated for the general involvement of microtubules and microfilaments in several membrane phenomena1–8. Usually, low concentrations of colchicine (μM concentrations) and related reagents have been used as the specific inhibitors for microtubules. In the case of phagocytosis, Ukena and Berlin reported that this reagent did not inhibit phagocytosis per se but affected molecular discrimination of membrane proteins during phagocytosis2. The mechanism of this interesting phenomenon has, however, not yet been explored.
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MIMURA, N., ASANO, A. Synergistic effect of colchicine and cytochalasin D on phagocytosis by peritoneal macrophages. Nature 261, 319–321 (1976). https://doi.org/10.1038/261319a0
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DOI: https://doi.org/10.1038/261319a0
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