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Immunological selection of tumour cells which have lost SV40 antigen expression

Abstract

In an already tumorigenic spontaneously transformed mouse cell, after further transformation by SV40, the virus-specific antigenic function becomes dominant. By transplantation into syngeneic mice SV40 antigen negative revertant tumour cells can be selected out.

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Mora, P., Chang, C., Couvillion, L. et al. Immunological selection of tumour cells which have lost SV40 antigen expression. Nature 269, 36–40 (1977). https://doi.org/10.1038/269036a0

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