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PERMEABILITY AND MOLECULAR CONSTITUTION AS FACTORS IN DRUG ACTION

Nature volume 152, pages 292–296 (1943)Cite this article

Abstract

ONE of the chief difficulties in the interpretation of the analogies between the biological activity of a drug and its behaviour in synthetic systems arises from the ambiguity of toxicological data, which may generally be correlated with solubility in the cell lipoids (Overton-Meyer), adsorption at cell interfaces (Traube), or with other physico-chemical factors. Moreover, these analogies may not hold when other biological systems and homologous series of drugs are compared. Recent work on molecular interaction in monolayers has provided a very valuable guide to the factors which influence specific drug reactivity in pharmacological systems1. The principles which have been advanced have greatly extended the implications of the original conceptions of Overton-Meyer and Traube.

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Authors and Affiliations

  1. Department of Colloid Science, Cambridge

    H. HURST

  2. Imperial College of Science and Technology, London

    H. HURST

Authors
  1. H. HURST
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HURST, H. PERMEABILITY AND MOLECULAR CONSTITUTION AS FACTORS IN DRUG ACTION. Nature 152, 292–296 (1943). https://doi.org/10.1038/152292a0

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