Abstract
IT is generally accepted that urinary steroids are excreted almost entirely in the form of water-soluble conjugates with glucuronic and sulphuric acids. Acid hydrolysis has been extensively used to liberate free steroids from these conjugates; but the conditions necessary for complete hydrolysis are such that considerable changes occur within the steroid molecules themselves, particularly the substitution of the hydroxyl group of androst-5-en-3-β-ol-17-one (dehydroisoandrosterone) by chlorine.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Beuhler, H. J., Katzman, P. A., and Doisy, B. A., Fed. Proc., 9, 157 (1950).
Henry, R., and Thevenet, M., Bull. Soc. Chim. Biol., 34, 886 (1952).
Henry, R., Thevenet, M., and Jarrige, P., Bull. Soc. Chim. Biol., 34, 897 (1952).
Dodgson, K. S., Lewis, J. I. M., and Spencer, B., Biochem. J., 51, xlii (1952). Dodgson, K. S., and Spencer, B., Biochem. J., 51, xliii (1952).
Jones, J. K. N., and Stitch, S. R., Biochem. J., 53, 679 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STITCH, S., HALKERSTON, I. Enzymatic Hydrolysis of Urinary Neutral 17-Ketosteroid Conjugates. Nature 172, 398–399 (1953). https://doi.org/10.1038/172398b0
Issue Date:
DOI: https://doi.org/10.1038/172398b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
