Abstract
IT has been shown by two of us1 that many aromatic primary and aromatic–aliphatic secondary amines can react with cyanguanidine to yield N1-aryl-N2-amidine-ureas and N1-aryl-N1-alkyl-N2-amidine-ureas respectively, under certain experimental conditions. (The reaction between the amines and cyanguanidine leading to arylbiguanides is already known.)
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References
Urbański, T., Skowrońska-Serafin, B., and Dabrowska, H., Roczniki Chem., 27, 65 (1953); 28, 423 (1954); 29, 450 (1955); Bull. Acad. Pol. Sci., Cl. III, 1, 74 (1953); 2, 453 (1954). Urbański, T., Skowrońska-Serafin, B., et al., Roczniki Chem., 30, 1189 (1956); 33, 1333, 1377, 1383 (1959); Bull. Acad. Pol. Sci., 4, 361, 363 (1956). Skowrońska-Serafin, B., and Urbański, T., Tetrahedron (in the press).
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CHIN, Y., WU, Y., SKOWROŃSKA-SERAFIN, B. et al. Antimalarial Properties of some Guanidine Derivatives. Nature 186, 170–171 (1960). https://doi.org/10.1038/186170a0
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DOI: https://doi.org/10.1038/186170a0
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