Abstract
OUR earlier experimental work using labelled thiosulphate has shown that the two atoms of sulphur in this compound have different fates in the course of metabolism in the animal organism1. In rats, the inner sulphur atom is eliminated very quickly from the organism in the form of sulphate, while the outer atom is transformed into the sulphate much more slowly, going probably through a number of intermediate stages. The results of our investigations have shown that the thiosulphate may be the metabolic precursor of the sulphate, and that, however small its concentration in rat urine may be, the endogenous pool of thiosulphate is large (ref. 1b).
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References
(a) Skarżyński, B., Szczepkowski, T. W., and Weber, M., Nature, 184, 994 (1959); (b) Ada Biochim. Polonica (in the press).
Gast, J. H., Arai, K., and Aldrich, F. L., J. Biol. Chem., 196, 875 (1952).
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SZCZEPKOWSKI, T., SKARŻYŃSKI, B. & WEBER, M. The Metabolic State of Thiosulphate. Nature 189, 1007–1008 (1961). https://doi.org/10.1038/1891007a0
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DOI: https://doi.org/10.1038/1891007a0
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