Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bone marrow spawns brain killers

The reduction in blood flow to the brain that causes a stroke triggers a deadly cascade of events that can lead to brain death. Studies in mice show that activation of an adenosine receptor on neutrophils invading the brain from the blood contribute to the damage (pages 1081–1087).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Adenosine aggravates neutrophils.

References

  1. Howard, G. & Howard, V.J. in Stroke: Pathophysiology, Diagnosis, and Management (eds. Moore, J.P., Choi, D.W., Grotta, J.C., Weir, B. & Wolf, P.A.) 3–12 (Churchill Livingstone, New York, 2004).

    Book  Google Scholar 

  2. Yu, L. et al. Nature Medicine 10, 1081–1087 (2004).

    Article  CAS  Google Scholar 

  3. Iadecola, C., Cho, S., Feuerstein, G.Z. & Hallenbeck, J. in Stroke: Pathophysiology, Diagnosis, and Management (eds. Moore, J.P., Choi, D., Grotta, J.C., Weir, B. & Wolf, P.) 883–894 (Churchill Livingstone, New York, 2004).

    Book  Google Scholar 

  4. Emerich, D.F., Dean, R.L., 3rd & Bartus, R.T. Exp. Neurol. 173, 168–81. (2002).

    Article  Google Scholar 

  5. Chen, J.F. et al. J. Neurosci. 19, 9192–9200 (1999).

    Article  CAS  Google Scholar 

  6. Chou, W.H. et al. J. Clin. Invest. 114, 49–56 (2004).

    Article  CAS  Google Scholar 

  7. Fredholm, B.B., AP, I.J., Jacobson, K.A., Klotz, K.N. & Linden, J. Pharmacol. Rev. 53, 527–552 (2001).

    CAS  PubMed  Google Scholar 

  8. Rudolphi, K.A., Schubert, P., Parkinson, F.E. & Fredholm, B.B. Trends Pharmacol. Sci. 13, 439–445 (1992).

    Article  CAS  Google Scholar 

  9. Marcoli, M. et al. Neuropharmacology 45, 201–210 (2003).

    Article  CAS  Google Scholar 

  10. von Lubitz, D.K. Eur. J. Pharmacol. 371, 85–102 (1999).

    Article  CAS  Google Scholar 

  11. Aden, U. et al. Stroke 34, 739–744 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iadecola, C. Bone marrow spawns brain killers. Nat Med 10, 1044–1045 (2004). https://doi.org/10.1038/nm1004-1044

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1004-1044

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing