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Effects of weight loss on serum 1,25-(OH)2-vitamin D concentrations in adults: A preliminary report

  • Clinical Investigations
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Summary

During a review of 42 metabolic studies in healthy women and men we observed that serum 1,25-(OH)2-D concentrations were directly correlated to the observed daily changes in body weight (r=0.68;P<0.001) and to caloric intake/kg/day (r=0.39;P=0.01). These relationships could not be accounted for by related and physiologically expected changes in serum Ca or iPTH concentrations. However, serum 1,25-(OH)2-D concentrations were observed to be inversely correlated to serum PO4 levels (r=−0.44;P=0.004). In addition, serum PO4 levels were inversely correlated to the daily changes in body weight (r=−0.40;P=0.009). Since dietary sodium intake averaged 142 mmol/day, it is unlikely that the observed changes in weight were the result of changes in salt and water balance. Thus it seems reasonable to speculate that serum 1,25-(OH)2-D concentrations may vary directly with energy balance, as reflected by changes in body weight. This effect may be mediated by alterations in PO4 metabolism. The accurate assessment of serum 1,25-(OH)2-D levels thus appears to require several measurements over time periods during which body weight is stable.

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Authors and Affiliations

  1. Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, 9200 West Wisconsin Avenue, 53226, Milwaukee, WI, USA

    J. Lemann Jr., R. W. Gray, W. J. Maierhofer & N. D. Adams

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  1. J. Lemann Jr.
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  2. R. W. Gray
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  3. W. J. Maierhofer
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  4. N. D. Adams
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Lemann, J., Gray, R.W., Maierhofer, W.J. et al. Effects of weight loss on serum 1,25-(OH)2-vitamin D concentrations in adults: A preliminary report. Calcif Tissue Int 36, 139–144 (1984). https://doi.org/10.1007/BF02405309

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  • DOI: https://doi.org/10.1007/BF02405309

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