Summary
Light- and electron-immunocytochemical investigation with the peroxidase-antiperoxidase (PAP) procedure revealed neuron-specific enolase and S-100 protein-like immunoreactivities specifically localized in the chief cells and the sustentacular cells of the rat carotid body, respectively. This finding suggests a neuron-like nature of the chief cells and a glia-like nature of the sustentacular cells on both embryological and functional bases.
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References
Adams WE (1958) The comparative morphology of the carotid body and carotid sinus. Charles C Thomas
Bock E (1978) Nervous system specific proteins. J Neurochem 30:7–14
Boyd JD (1937) The development of the human carotid body. Contrib Embryol Carnegie Inst 26:1–31
Cocchia D, Michetti F (1981) S-100 antigen in satellite cells of the adrenal medulla and the superior cervical ganglion of the rat. Cell Tissue Res 215:103–112
Gomez LP (1908) The anatomy and pathology of the carotid gland. Am J Mwd Sci 136:98–111
Hamilton WJ, Mossman HW (1972) Human embryology. Williams and Wilkins Co, Baltimore
Kohn A (1900) Über den Bau und die Entwicklung der sog. Carotisdrüse. Arch mikr Anat 56:81–148
Kondo H (1975) A light and electron microscopic study on the embryonic development of the rat carotid body. Am J Anat 144:275–294
Kondo H (1977) Innervation of the chief cells of the carotid body: An ultrastructural review. Arch Histol Jpn 40:Suppl 221–230
Le Douarin N, Le Lièvre C, Fontaine J (1972) Embryology expérimentale recherches expérimentales sur l'origine embryologique due corps carotidien chez les oiseux. C R Acad Sci Paris t 275:583–586
Marangos PJ, Schmechel D, Zis AP, Goodwin FK (1979) The existence and neurobiological significance of neuronal and glial forms of the glycolytic enzyme enolase. Biol Psych 14:563–579
Møller M, Ingild A, Bock E (1978) Immunohistochemical demonstration of S-100 protein and GFA protein in interstitial cells of rat pineal gland. Brain Res 140:1–13
Nakajima T, Yamaguchi H, Takahashi K (1980) S-100 protein in folliculostellate cells of the rat pituitary anterior lobe. Brain Res 191:523–531
Nakajima T, Sato Y, Watanabe S, Kameya T, Shimosato Y (1981) Immunohistochemical demonstration of neuron-specific enolase in carcinoid tumor. In: Proceeding of 40th Annual Meeting of Jap Cancer Assoc, 1149
Pearse AGE, Polak JM, Rost FWD, Fontaine Y, Le Lievre C, Le Douarin N (1973) Demonstration of the neural crest origin of type I (APUD) cells in the avian carotid body, using a cytological marker system. Histochemie 34:191–203
Rabl H (1922) Die Entwicklung der Carotisdrüse beim Meerschweinchen. Arch mikr Anat 96:315–339
Schmechel D, Marongos PJ, Brightman M (1978) Neuron-specific enolase is a molecular marker for peripheral and central neuroendocrine cells. Nature 276:834–836
Stefansson K, Wollmann RL, Moore BW (1982) Distribution of S-100 protein outside the central nervous system. Brain Res 243:309–317
Sternberger LA (1974) Immunocytochemistry. Prentice-Hall, Englewood Cliffs, N J
Watzka M (1938) Über die Entwicklung des Paraganglion Caroticum der Säugetiere. 2. ges Anat 1. 2. Anat Entwickl Gesch 108:61–73
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Kondo, H., Iwanaga, T. & Nakajima, T. Immunocytochemical study on the localization of neuron-specific enolase and S-100 protein in the carotid body of rats. Cell Tissue Res. 227, 291–295 (1982). https://doi.org/10.1007/BF00210887
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DOI: https://doi.org/10.1007/BF00210887